1. B-lactam antibiotics (class) name drugs
    • penicillin
    • cephalosporin
  2. aminoglycosides (class) overview
    • bactericidal
    • most effective against G-ve bacteria
    • given as injection
    • gd in alkaline conditions so gd to tx UTIs
    • resistance to these developes quickly due to inactivation by bacterial enzymes
    • side effects include vestibular + audtory toxicity
  3. aminoglycosides (class) name drugs
    • streptomycin
    • neomycin
    • gentamycin- only one effective against pseudomonas spp
  4. tetracyclins (class) overview
    • bacteriostatic- bind to A site in ribosomes
    • X bbb, widely distributed, orally absorbed
    • wide spectrum of activity
    • recycled thro bile so gd for liver/bilary/gut infections
    • side effects- superinfection (rare)
    • common plasmid transmitted resistance
  5. tetracyclins (class) name drugs
    • chlortetracycline
    • oxytetracyline
  6. macrolides & lincosamides (classes) overview
    • disrupt completion of peptide chains
    • should not give with chloramphenicol (same binding site)
    • distributes well, doesn't X bbb, excretion is renal
    • static/cidal is dose dependent
    • mostly effective against G+ve
    • GI upset and vomiting (rare)
    • plasmid carried resistance
    • !inhibs cytochrome p450 which warfarin needs to work!
  7. macrolides & lincosamides (classes) name drugs
    • erythromycin- acid unstable but may be administered in coated tablets
    • spiramycin
    • clindamycin
  8. chloramphenicol (class) overview
    • bacteriostatic
    • distribution gd, x bbb
    • inactivated in the liver by glucuronidation
    • may accumulate in cats to irreversibly suppress bone marrow
    • bacterial resistance through chloramphenicol acetyl transferase
  9. chloramphenicol (class) name drugs
    • chloramfenicol
    • florfenicol
  10. sulphonamides & trimethoprim (classes) overview
    • target folate synthesis to stop nucleic acid synthesis
    • gd tissue penetration, eliminated by kidney
    • static/cidal dose dependent
    • gd spectrum of activity
    • resistance widespread
  11. sulphonamides & trimethoprim (classes) name drugs
    anything beginning sulfa- or sulpha-
  12. quinolones (class) overview
    • given orally, eliminated by kidney and liver
    • inhibits DNA gyrase which usually packages DNA into cell
    • bactericidal, v effective
    • resistance is slow to develope
  13. quinolones (class) name drugs
    nalidixic acid and difloxacin
Card Set