Sedative Drugs

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phenothiazine (class) name drugs
- acepromazine
- chlorpromazine
- methotrimprazine
- promethazine
phenothiazine (class) name effects
- sedative
- anti-emetics (tx)
- vasodilation (a1 adrenoR antagonist)
- antipsychotic
- lack of analgesic action
acepromazine considerations for use
- decreases seizure threshold
- can cause penis prolapse/paralysis in stallions
- vasodilation
butyrophenones (class) name drugs
- haloperidol
- droperidol
- fluanisone
- azaperone (pigs only)
butyrophenones (class) name effects
- sedative
- anti-emetic
butyrophenones (class) name side effects
- moderate hypotension (a1 blocker)
- extrapyramidal effects at high doses
a2 adrenoreceptor agonists (class) name drugs
- xylazine
- medetomidine
- detomidine
a2 adrenoreceptor agonists (class) name effects
- (inhibit NA release)
- sedation
- analgesia
- mm relaxation
- rapid reversibility with antagonists
- prevent CNS stim and mm rigidity assoc with ketamine and some opioids
a2 adrenoreceptor agonists (class) name side effects
- decreased CO, bradycardia
- increase then decrease in BP
- hyperglycaemia
- diuresis (decrease ADH secretion)
drugs to sedate horses
- xylazine
- detomidine
- romifidine
behavioural effects of xylazine/medetomidine in dogs and cats
- heavy sedation but arousable
- recumbancy
- vomit (especially cats)
a2 adrenoreceptor agonist CV effects
- vasoC initially- hypertension then hypotension
- severe bradycardia
- decreased CO
a2 adrenoreceptor agonists effects in large animals
- mild resp acidosis
- sweating
- uterine contraction in cattle with xylazine (pregnant animals)
a2 adrenoreceptor agonists effects in small animals
- gums are white from vasoC
- vomiting
anatagonists to reverse sedation of xylazine
- yohimbine in dogs
- tolazoline in large animals
anatgonist to reverse sedation of medetomidine/detomidine

atipamezole in dogs and horses
a2 adrenoreceptor agonists- considerations
- CNS depressioon-overdose risk
- HR/CO may worsen CV dz
- vomiting
- increases peeing. rupture if urethra obstruction
- hyperglycaemia (diabetes, preg)
- uterine contraction, abortion in last trimester of preg
ketamine
- NMDA R channel blocker
- sedative
- drug of abuse
- dissociative analgesia
tiletamine
- gd analgesia
- comes combined with others
- used for sedating horses

Author

rach394

57092

Card Set

Sedative Drugs

Description

sedative drugs

Updated

2010-12-23T11:11:58Z

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