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Sedative Drugs
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phenothiazine (class) name drugs
acepromazine
chlorpromazine
methotrimprazine
promethazine
phenothiazine (class) name effects
sedative
anti-emetics (tx)
vasodilation (a1 adrenoR antagonist)
antipsychotic
lack of analgesic action
acepromazine considerations for use
decreases seizure threshold
can cause penis prolapse/paralysis in stallions
vasodilation
butyrophenones (class) name drugs
haloperidol
droperidol
fluanisone
azaperone (pigs only)
butyrophenones (class) name effects
sedative
anti-emetic
butyrophenones (class) name side effects
moderate hypotension (a1 blocker)
extrapyramidal effects at high doses
a2 adrenoreceptor agonists (class) name drugs
xylazine
medetomidine
detomidine
a2 adrenoreceptor agonists (class) name effects
(inhibit NA release)
sedation
analgesia
mm relaxation
rapid reversibility with antagonists
prevent CNS stim and mm rigidity assoc with ketamine and some opioids
a2 adrenoreceptor agonists (class) name side effects
decreased CO, bradycardia
increase then decrease in BP
hyperglycaemia
diuresis (decrease ADH secretion)
drugs to sedate horses
xylazine
detomidine
romifidine
behavioural effects of xylazine/medetomidine in dogs and cats
heavy sedation but arousable
recumbancy
vomit (especially cats)
a2 adrenoreceptor agonist CV effects
vasoC initially- hypertension then hypotension
severe bradycardia
decreased CO
a2 adrenoreceptor agonists effects in large animals
mild resp acidosis
sweating
uterine contraction in cattle with xylazine (pregnant animals)
a2 adrenoreceptor agonists effects in small animals
gums are white from vasoC
vomiting
anatagonists to reverse sedation of xylazine
yohimbine in dogs
tolazoline in large animals
anatgonist to reverse sedation of medetomidine/detomidine
atipamezole in dogs and horses
a2 adrenoreceptor agonists- considerations
CNS depressioon-overdose risk
HR/CO may worsen CV dz
vomiting
increases peeing. rupture if urethra obstruction
hyperglycaemia (diabetes, preg)
uterine contraction, abortion in last trimester of preg
ketamine
NMDA R channel blocker
sedative
drug of abuse
dissociative analgesia
tiletamine
gd analgesia
comes combined with others
used for sedating horses
Author
rach394
ID
57092
Card Set
Sedative Drugs
Description
sedative drugs
Updated
2010-12-23T11:11:58Z
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