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What are major types of plasma proteins? What are their physiological role? What is their function?
- Albumin: most abundant plasma protein (60%)
- transports free fatty acid, thyroxine, Ca2+, drugs
- maintains osmotic pressure of blood
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What are the causes and consequences of Hypoalbuminaeima?
- Causes: liver disease, nephrotic syndrome, vascular permeability, malnutrition
- Consequences: edema, concentration of free drugs
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What are Acute-phase proteins? Name 8 types
- Acute-phase proteins: up and down in concentration more than 25% after infection
- C-reactive protein
- A,AT
- Ceruloplasmin
- Haptoglobin
- Retinol-binding protein
- Transthyretin
- Alpha-fetoprotein
- Immunoglobulin
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Talk to me about C-reactive protein
- binds to bacteria or dead tissue and activates complement system
- detects infection after surgery
- management of neonatal septicemia and meningitis
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Talk to me about Alpha Anti-Trypsin
- Protease inhibition
- e.g: inhibits elastase
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Talk to me about Ceruloplasmin
- major copper carrying protein
- oxidizes Fe2+ to Fe3+ for incorporation in transferrins
- Wilson's disease: inability to invest copper in protein
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