What effect does nicotine have on health?
none - it has addictive effects only
What are the chemical properties of nicotine?
it's a base
31% un-ionized at physiological pH - able to cross cell membranes
inhalation rate of absorption comparable to IV administration
How fast can nicotine reach the brain?
What determines the oral absorption of nicotine?
the pH of the
cigs have little absorption (pH 5.5)
pipe/cigar/smokeless have rapid absorption (pH 8.5)
What is the half-life of nicotine?
What does it take to achieve accumulation of nicotine?
regular smoking for 6-8h
When is the concentration of nicotine in the blood highest?
at the end of the cigarette
What are the pharmacologic effects of nicotine?
stimulant and depressant actions
What neurotransmitters are released by nicotine?
What effects are produced by nicotine stimulation of the CNS?
relief of anxiety
improved task performance
What effects are produced by nicotine stimulation of the cardiovascular system?
What effects other than those of the CNS and cardiovascular does nicotine have?
increased metabolic rate
skeletal muscle relaxation
What are the effects of DA after nicotine stimulation?
How fast can tolerance be developed to nicotine?
a single day
can regain some sensitivity by abstaining overnight
What are the sx of nicotine w/d?
What effects does nicotine have on P450?