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What is Frederich Griffith responsible for?
Transformation
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Define transformation?
The incorporation of genetic material into a cell thereby changing its pheneotype.
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What are Hershy and Chase responsible for?
They found out that DNA was being past from generation to generation not protien by using bacterophage.
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What does the semiconservitive model of DNA repliction mean or say?
Double staranded DNA is replicated by first seperating the double stranded DNA.
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What enzyme replicates DNA?
DNA polymerase.
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A new DNA strand is always going to be synthesized in which direction?
5'---->3'(5 prime to 3 prime).
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What does 5'---->3' mean?
Carbons on the pentose sugar.
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Two stands of double stranded exhibit antiparallel orientation, what does that mean?
They have oppisite 5'--->3' direction.
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What are Francis Cricks contributions?
- DNA double helix
- Central Dogma of biology
- Wobble
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What is central dogma refering to and is it an absolute rule?
- It is a very generalized explanation of gene expression(DNA-->RNA-------->Polypeptide).
- No(not an absolute rule).
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Are there some exceptions to central dogma?
Yes(RNA viruses).
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Transcription vs. Translation?
- Transciption is the synthisis of RNA from a DNA template
- Translation is using messanger RNA as the source for the genetic code or the instruction to produce polypeptide
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Do prokayotes and enkayotes do translation and transcription the same?
- NO
- Coupled transcription and translation(prokaryotes)
- Transcription happens in the nucleus and translation begins in the cytosol(eukaryotes).
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What are the steps of transcription?
- Initiation (bring everything together that it needs).
- Elongation(RNA polymerase is going to add the RNA nucleotide to the transcription).
- Termination(stops transcription).
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What are transcription factors?
Small protien that are neccassay for the binding of the RNA polymerase to the promoter.
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What the genetic code and its attributes?
- The nuclaic acid RNA.
- Triplet code or nucleotide triplets.
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What are codons and there function?
- Messanger RNA nucleotide triplets.
- They specify for amino acid.
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With respect to the coding of amino acid there are two attributes?
- Unambiguity(clear, or certain)each codon is specific for only one amino acid.
- Redundancy, theres more then one possible codon for those amino acids.
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Start codon vs. stop codon?
- Start codons say start translating, they specify for an amino acid.
- Stop codons dont specify for an amino acid they just say stop translating.
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What is the reading frame?
It is how the messanger RNA is going to be divided into codons.
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Define mRNA?
Type of nuclaic acid in which the genetic code is defined , contains the instructions for polypeptide.
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Define tRNA?
Transfers amino acids from cytosol and brings them to site of translation.
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Define anticodon?
For each tRNA it contains only one nucleotide triplet.
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What is wobble?
The relaxation of those bas pairing rules, your not getting strict base paring(redundancy).
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In what direction is the new RNA transcript transcribed?
5'--->3'(5 prime to 3 prime).
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What is aminoayl-tRNA synthetase?
It catalises the reaction that adds an amino acid to a tRNA.
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What is the initiator tRNA?
- Different from other tRNA.
- Binds to start codon.
- Its the only RNA that comes in during the initiating phase of translation.
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How is the eukaryotic primary transcript edited or processed to mRNA?
- First step you add 5' cap to the the 5' end?
- Second step you cut out introns(no coding region)then splice together exons(exspressable portion of gene or mRNA sequence).
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What are polyribosomes?
A multiable number of ribosomes attached to an mRNA during translation
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What is a retrovirus?
A particular type of a RNA virus which is an exception to central dogma, and the preform reverse transcription.
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What is reverse transcription?
- RNA to produce DNA
- Which requires the enzyme reverse transciptase.
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Where would a provirus be located?
- Inside a host cells genome
- which is viral DNA
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What are mutations?
Heritable changes in the genetic code.
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What are some mutations?
- Spontaneous, mutation that is a biological error.
- Induced mutation, means it was exsposed to something like a chemical or radiation.
- Frameshift, change in the reading frame
- substition(synonymous no change)(Nonsynonymous did involve a change.
- Nonsense, a premature stop codon
- Missence, going to end up with a different amino acid.
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What are species concepts?
Different ideas of what a species is.
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Why are Charles Darwin and Alfred Russell Wallace rememberd?
They independently came up with the concept of natural selection.
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Define natural selection?
The mechinism of evolution proposed by Darwin.
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What is artificial selection?
Selection by humans of traits that are desirable in plants and animals.
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What is the synthetic theory?
Interaction between evolution and genetics within a population.
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What are some of the different lines of evidence in support of evolution mentioned in class?
- Fossil evidence.
- Comparitive and developemental anatomy.
- Bio geography.
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What is an index fossil?
Fossil restricted to a narrow period of geologic time and found in the same sedimentary layers in different geographic areas.
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What type of materials are the basis for a radiometric dating?
Radioactive isotopes.
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What is a half life?
The amount of time it takes for half the sample to decay from the parential isotopes to the duaghter isotopes.
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What is the differnce between a homology and homplasy?
- Homology indicate evolutionary relationships.
- Homoplasy adatation features.
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What is Alfred Wegener responsible for?
- Continental Drift
- Therory of the super continent Pangea
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Are continental drifts and plate tectonics the same?
- No
- Plate tectonics is an updated version of Wegeners continental drift theory.
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What is population genetics?
Study of evolution whithin population, how population require genetic changes and variation.
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What is a gene pool?
All the genetic materail within a population.
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What is microevolution?
Evolutionary changes whithin a species.
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Hardy Wienberg equallibrium?
- Allele frequencys do not change from generation to generation in a large population.
- If its not evolving its IN Hardy Wienberg.
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What are the conditions of Hardy Wienberg?
- Random mating
- Large population
- No mutations
- No migrations
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How does Hardy Wienberg rekate to synthetic Theory?
They both talk about evolution and the change in allele frequency.
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What is inbreeding?
Mating between closely related individuals(violates Hardy Wienberg).
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What is inbreeding depression?
The phenomemom in which inbred offspring of genetically similiar individuals have a lower fitness.
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What is going on during assortative mating?
Sexual reproduction in which individuals pair nonrandomly- select mate based on phenotype(violates Hardy Wienberg).
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How does a mutation affect Hardy Wienberg?
- At first little or no effect.
- Only if mutation persists in a population does it affect it.
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What does genetic drift refer to and what types are there?
- Some sort of random fluctuation in allele frequency.
- Bottleneck, starts with a large population and the bulk of the population dies off.
- Founder effect, individuals leave a large population and start new population so there allele frequancy will be different from the population they left, eventually.
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How does genetic drift(founder effect, bottleneck)effect Hardy Wienberg?
By changing the allele and genotype frequency from the original population.
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