MED-Naloxone

Narcotic antagonist

Competes for, and dispaces, narcotic molecules from opiate receptors in the brain

• Opiate overdose
• Coma of unknown origin

Hypersensitivity

Use caution on narcotic physically-dependent patients as naloxone can cause abrupt reversal of narcotic effects

• N/V
• HTN
• Ventricular arrhythmias
• Tachycardia
• Hyperventilation
• Tremors

May cause narcotic withdrawal in the narcotic-dependent patient so administer only enough to reverse respiratory depression

• Adult: 0.4-2 mg IVP/IM/SQ/ET q 2-3 mins max 10 mg
• (double dose if administering ET)

• Pedi: 0.1 mg/kg IVP/IO/IM/ET/SQ
• (double dose if ET)
• q 2-3 mins max 10 mg

• Onset: 2-10 mins IM/ET, <2 mins IV
• Duration: 20-120 mins
• Half-life: 60-90 mins