pharmacology exam

inhibit bacterial cell wall synthesis
vancomycin is the only glycopeptide antibiotic available

inhibit cell wall funtion
Polymyxin B is an example of an antibiotic that interferes with cell wall function

inhibit protein synthesis - 5 classes:
aminoglycosides
macroslides
tetracylines
amphenicols
oxazolidiones

inhibit bacterial RNA & DNA synthesis
fluroquinolones (e.g. ciprofloxacin)
nitroimidazoles (e.g. metronidazole)

antifolates
^{Folic acid is needed for bacterial synthesis of DNA (needs to make its own) from para-aminobenzoic acid (PABA)}
antifolate antiinfective agents (e.g. sulfonamides)
dihydrofolate reductase inhibitors (e.g. trimethoprim)
they block bacterial synthesis of folic acid

microbial resistance is the ability of bacteria to overcome the bactericidal effects of an antibiotic

Sulfonamides are anti-folate drugs

trimethoprim is a dihydrofolate reductase inhibitor.

Aminoglycosidesis A common ending of-” mycin “.
Use:Serious infections of the bone, abdomen, heart, zbrain, urinary tract, reproductive system, skin, and kidneys: Examples –inflammatory disease, osteomyelitis, peritonitis, endocarditis, pelvic
Treatment of blepharitis and conjunctivitis
Bowel sterilization prior to bowel surger