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Antineoplastic Agents
Suppress the growth of cells and attempt to destroy the spread of malignant cells
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Antineoplastic Drugs
- Drugs destroy cells that are undergoing division
- Can be cell cycle specific or non-specific
- Specific- Antimetabolites, bleomycin, vinca alkaloids, podophyllin
- Non-specific- Alkylating agents, antibiotics, Cisplatin, Nitrosoureas
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Cell Destruction Order
Hair is most effected-nerves are least effected
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Adverse Drug Effects
- Bone Marrow Suppression
- Gastrointestinal effects
- Dermatological effects
- Hepatotoxicity
- Neurologic effects
- Nephrotoxicity
- Immunosuppression
- Germ cells
- Oral Effects
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Oral Effects
- Pain gums, mucosa and teeth
- Ulcerations and gingival hemorrhage
- Dryness and impaired taste sensation
- Petechiae on hard palate
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