-
Dobutamine
Beta-1 Adrenergic Receptor AGONIST
-
Acebutolol
- Beta-1 Adrenergic Receptor ANTAGONIST
- Sectral
-
Atenolol
- Beta-1 Adrenergic Receptor ANTAGONIST
- Tenormin
-
Betaxolol
- Beta-1 Receptor Adrenergic ANTAGONIST
- Kerlone
-
Bisprolol
- Beta-1 Receptor Adrenergic ANTAGONIST
- Zebeta
-
Metoprolol
- Beta-1 Receptor Adrenergic ANTAGONIST
- Toprol XL, Lopressor
-
Esmolol
- Beta-1 Receptor Adrenergic ANTAGONIST
- Brevibloc
-
Albuterol
- Beta-2 Adrenergic Receptor AGONIST
- ProAir, Proventil
-
Bitolterol
- Beta-2 Adrenergic Receptor AGONIST
- Tornalate
-
Formoterol
- Beta-2 Adrenergic Receptor AGONIST
- Foradil
-
Isoetharine
Beta-2 Adrenergic Receptor AGONIST
-
Levabuterol
- Beta-2 Adrenergic Receptor AGONIST
- Xopenex
-
Metaproterenol
- Beta-2 Adrenergic Receptor AGONIST
- Alupent
-
Pirbuterol
- Beta-2 Adrenergic Receptor AGONIST
- Maxair
-
Salmeterol
- Beta-2 Adrenergic Receptor AGONIST
- Serevent
-
Terbutaline
Beta-2 Adrenergic Receptor AGONIST
-
Ritodrine
Beta-2 Adrenergic Receptor AGONIST
-
Isoproterenol
- Non-Selective Beta-Adrenergic Agonist
- both Beta-1 and Beta-2
- Isuprel
-
Propranolol
- Non-Selective Beta-ANTAGONIST
- Inderal
-
Nadolol
- Non-Selective Beta-ANTAGONIST
- Corgard
-
Pindolol
Non-Selective Beta-ANTAGONIST
-
Timolol
Non-Selective Beta-ANTAGONIST
-
Sotalol
- Non-Selective Beta-ANTAGONIST
- Betapace
-
Levobunalol
Non-Selective Beta-ANTAGONIST
-
Midodrine
Selective Alpha-1 Receptor AGONIST
-
Phenylephrine
Selective Alpha-1 Receptor AGONIST
-
Pseudoephedrine
- Selective Alpha-1 Receptor AGONIST
- Sudafed
-
Oxymetazoline
- Selective Alpha-1 Receptor AGONIST
- Afrin
-
Prazosin
- Selective Alpha-1 Receptor ANTAGONIST
- Minipress
-
Terazosin
- Selective Alpha-1 Receptor ANTAGONIST
- Hytrin
-
Doxazosin
- Selective Alpha-1 Receptor ANTAGONIST
- Cardura
-
Alfuzosin
- Selective Alpha-1 Receptor ANTAGONIST
- Uroxatral
-
Tamsulosin
- Selective Alpha-1 Receptor ANTAGONIST
- Flomax (Alpha-1A)
-
Yohimbine
- Selective Alpha-2 Receptor ANTAGONIST
- works in the CNS
-
Clonidine
- Selective Alpha-2 Receptor AGONIST
- Catapres
-
Methyldopa
Selective Alpha-2 Receptor AGONIST
-
Guanabenz
Selective Alpha-2 Receptor AGONIST
-
Guanfacine
- Selective Alpha-2 Receptor AGONIST
- Tenex,Intuniv
-
Brimonidine
- Selective Alpha-2 Receptor AGONIST
- Alphagan
-
Dexmedetomine
- Selective Alpha-2 Receptor AGONIST
- Precedex
-
Apraclonidine
- Selective Alpha-2 Receptor AGONIST
- Iopidine
-
Labetalol
- Beta-1, Beta-2, and Alpha-1 Receptor ANTAGONIST
- Trandate
-
Carvedilol
- Beta-1, Beta-2, and Alpha-1 Receptor ANTAGONIST
- Coreg
-
Phentolamine
- Non-Selective Alpha ANTAGONIST
- OraVerse
-
Phenoxybenzamide
Non-Selective Alpha ANTAGONIST
-
General Effects of Alpha-1 Receptor Activation??
Overall Effects??
- General: vasoconstriction, capillary constriction, decreased urination, mydriasis
- Overall: Increase TPR, and get reflex decrease in HR
-
General Effects of Alpha-2 Receptor Activaiton?
Overall Effects?
- General: decrease firing of sympathetic neurons, decrease release of NE at the nerve ending, decrease aqueous humor production
- Overall: decrease TPR, decrease BP, and decrease HR
-
General Effects of Beta-2 Receptor Activation??
Overall Effects?
- General: bronchodilation, uterine relaxation, vasodilation, gylcogenolysis, gluconeogenesis, increase in the production of aqueous humor
- Overall: relaxation, decreased TPR, and again reflex increase HR
-
General Effects of Beta-1 Receptor Activation??
Overall Effects?
- General: SA node increased firing, AV node increased nodal conduction, increased contractility, increased stroke volume, increased automaticity, increased renin secretion
- Overall: Direct increase in HR
-
Clidinium
Muscarinic Receptor ANTAGONIST
-
Propantheline
Muscarinic Receptor ANTAGONIST
-
Mepenzolate
Muscarinic Receptor ANTAGONIST
-
Cyclopentolate
- Muscarinic Receptor ANTAGONIST
- Cyclogyl
-
Tropicamide
- Muscarinic Receptor ANTAGONIST
- Mydriacyl
-
Glycopyrrolate
- Muscarinic Receptor ANTAGONIST
- Robinul
-
Tolterodine
- Muscarinic Receptor ANTAGONIST
- Detrol
-
Oxybutinin
- Muscarinic Receptor ANTAGONIST
- Ditropan
-
Flavoxate
- Muscarinic Receptor ANTAGONIST
- Urispas
-
Dicyclomine
- Muscarinic Receptor ANTAGONIST
- Bentyl
-
Hyoscyamine
- Muscarinic Receptor ANTAGONIST
- Levsin
-
Scopolamine
- Muscarinic Receptor ANTAGONIST
- Transderm-Scope
-
Belladonna
Muscarinic Receptor ANTAGONIST
-
Ipratropium
- Muscarinic Receptor ANTAGONIST
- Atrovent
-
Tiotropium
- Muscarinic Receptor ANTAGONIST
- Spiriva
-
Atropine
- Muscarinic Receptor ANTAGONIST
- AtroPen
-
Darifenacin
- Muscarinic Receptor ANTAGONIST
- Enablex
-
Solifenacin
- Muscarinic Receptor ANTAGONIST
- Vesicare
-
Trospium
- Muscarinic Receptor ANTAGONIST
- Sanctura
-
Bethanechol
- Muscarinic Receptor AGONIST
- Urecholine
-
Carbachol
Muscarinic Receptor AGONIST
-
Cevimeline
- Muscarinic Receptor AGONIST
- Evoxac
-
Pilocarpine
- Muscarinic Receptor AGONIST
- Salagen
-
Physostigmine
Cholinesterase Inhibitor
-
Pyridostigmine
- Cholinesterase Inhibitor
- Mestinon
-
Ambenonium
- Cholinesterase Inhibitor
- Mytelase
-
Malathion
- Cholinesterase Inhibitor
- Ovide
-
Neostigmine
- Cholinesterase Inhibitor
- Prostigmin
-
Edrophonium
- Cholinesterase Inhibitor
- Enlon
-
Echothiophate
- Cholinesterase Inhibitor
- Phospholine Iodide
-
Botulinum Toxin
- Indirect Sympatholytic
- Botox
-
Gaunethidine
Indirect Sympatholytic
-
Guanadrel
Indirect Sympatholytic
-
Reserpine
Indirect Sympatholytic
-
Metyrosine
- Indirect Sympatholytic
- Demser
-
Cisatracurium
Muscle Nicotinic Receptor Antagonist
-
Rocuronium
Muscle Nicotinic Receptor Antagonists
-
Mivacurium
Muscle Nicotinic Receptor Antagonist
-
Rapacuronium
Muscle Nicotinic Receptor Antagonist
-
Pipecuronium
Muscle Nicotinic Receptor Antagonist
-
Pancuronium
Muscle Nicotinic Receptor Antagonist
-
Vecuronium
Muscle Nicotinic Receptor Antagonist
-
Doxacurium
Muscle Nicotinic Receptor Antagonist
-
Atracurium
Muscle Nicotinic Receptor Antagonist
-
Nicotine
Central Acting Nicotinic Receptor AGONIST
-
Varenicline
- Centrally Acting Nicotinic Receptor PARTIAL AGONIST
- Chantix
-
Succinylcholine
Muscle Nicotinic Receptor AGONIST (the only 1)
-
General Effects of Cholinesterase Inhibitors??
Overall?
- General: increase bronchoconstriction, increase GI motility, increase urination, miosis, increase glandular secretions
- Overall: enhance the effects of the PNS
-
General Effects of Muscarinic Receptor Activation??
Overall?
- General: increase bronchoconstriction, increase GI motility, increase urination, miosis, increase glandular secretions
- Overall: enhance the effects of the PNS
-
General Effects of Muscle Nicotinic Receptor Antagonists??
Overall?
- General: inhibit Ach at the neuromuscular end plate
- Overall: muscle paralysis
-
General Effects of Indirect Sympatholytics??
Overall?
- General: inhibit post-ganglionic functioning of the SNS by blocking NE
- Overall: antihypertensives decrease both HR and vessel resistance
-
General Effects of Nicotinic Receptor Ligands??
Overall?
- General: stimulation causes muscle contraction, and in the brain some may be linked to reward centers
- Overall: Muscle contraction
-
Acetazolamide
- Diuretic: Carbonic Anhydrase Inhibitor
- Diamox
-
Methazolamide
- Diuretic: Carbonic Anhydrase Inhibitor
- Neptazane
-
Darzolamide
- Diuretic: Carbonic Anhydrase Inhibitor
- Trusopt
-
Furosemide
- Loop Diuretics "High Ceiling"
- Lasix
-
Bumetanide
- Loop Diuretics "High Ceiling"
- Bumex
-
Torsemide
- Loop Diuretics "High Ceiling"
- Demadex
-
Ethacrynic Acid
- Loop Diuretics "High Ceiling"
- Edecrin
-
Hydrochlorothiazide
- Thiazide Diuretic
- Hydrodiuril
-
-
-
Metolazone
- Thiazide Diuretic
- Zoroxolyn
-
Amiloride
- Na Channel Inhibitors/ K-sparing Diuretics
- Midamor
-
Triamterene
- Na Channel Inhibitors/ K-sparing Diuretics
- Dyrenium
-
Spirinolactone
- Aldosterone Antagonists/ K-sparing Diuretics
- Aldactone
-
Eplerenone
- Aldosterone Antagonists/ K-sparing Diuretics
- Inspra
-
Mannitol, Urea, Glycerin
Osmotic Diuretics
-
Nifedipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- Procardia
-
Nislodipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- Sular
-
Nicardipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- Cardene
-
Nitrendipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- Baypress
-
Felodipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- Plendil
-
Amlodipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- Norvasc
-
Nimodipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- Nimotp
-
Isradipine
- Calcium Channel Blockers; 1,4 Dihydropyridines
- DynaCirc
-
Verapamil
- Calcium Channel Blockers; Arylalkyl Amines
- Isoptin, Calan
-
Bepridil
- Calcium Channel Blockers; Arylalkyl Amines
- Vascor
-
Diltiazem
- Calcium Channel Blocker; Benzothiazepine
- Cardiazem
-
Ephedrine
Indirect Acting Sympathomimetics
-
General Effects of Indirect Acting Sympathomimetics??
Overall?
- General: mimic the actions of the sympathetic nervous system
- Overall: direct agonist at alpha-1, beta-1, and beta-2 SO good decongestant (vasoconstriction), increases HR, and good bronchodilators
-
Ma Huang
- Indirect Acting Sympathomimetic
- potent stimulant of beta-1 receptors
-
Dopamine
- Catecholamine: D1 (Gs) receptors on smooth muscle
- If DA given exogenously get vasodilation mainly in the renal artery increasing perfusion to the kidney also increasing GFR;
- some affinity for beta-1 so may increase HR;
- some affinity for alpha-1 so some vasoconstriction (NOT desired)
- TX: oliguria and bradycardia
-
Fenoldapam
- D1 AGONIST
- TX: hypertensive crisis w/ or w/o oliguria
- Corlopam
-
Epinephrine
- ULTIMATE ADRENERGIC AGONIST
- Alpha-1, Alpha-2, Beta-1, Beta-2
-
Vasopressin (ADH)
- AGONIST V2(collecting duct) and V1(vascular and gastric sm. muscle) Receptors
- V2 = increase # aquaporins so increase H2O reabsorption
- V1 = vasoconstriction, reduce GI bleeds
-
Desmopressin (DDAVP)
- AGONIST V2(collecting duct)
- Nocturnal Enuresis (bedwetting)
-
General Effects of ACE Inhibitors?
- Treat Hypertension: via decrease in SVR, decrease in mean diastolic and systolic pressures, also left ventricular systolic dysfunction (mild asymptomatic to HF), and renal protection DM and non-DM to slow progression of renal disease
- This increases compliance of large arteries, no increase in sympathetic tone or cardiac output with treatment, also no BP changes with postural changes or exercise
-
-
-
-
-
-
-
-
-
-
-
General Effects of ARBs??
- TX: hypertension, renal protection in DM and non-DM to slow progression of renal disease, overt diabetic nephropathy, HF when intolerant to ACEIs
- Contracts vascular smooth muscle, release of adrenal catecholamines thus enhances noradrenergic neurotransmission, increase sympathetic tone, secretion of ADH and aldosterone
-
Candesartan
- ARB: Insurmountable
- Atacand
-
Olmesartan
- ARB: Insurmountable
- Benicar
-
Irbesartan
- ARB: Insurmountable
- Avapro
-
Telmisartan
- ARB: Insurmountable
- Micardis
-
-
-
-
General Effects of Direct Renin Inhibitors??
- TX: hypertension reducing BP comparable to ACEIs and ARBs
- Prevents generation of Ang I from angiotensinogen, competitive inhibitor of renin enzymatic activity
-
Aliskiren
- Direct Renin Inhibitors
- Tekturna
-
General Effects of Organic Nitrates??
- TX: angina
- Reduces preload and cardiac work load via venous dilation and increases supply of O2 via arterial dilation
-
-
-
-
Nitroprusside
- Direct Vasodilator: Nitro-vasodilator
- NitroPress
-
Hydralazine
- Direct Vasodilator
- Apresoline
-
Hydralazine/Isosorbide Dinitrate
-
Minoxidil
Direct Vasodilator
-
Diazoxide
- Direct Vasodilator
- Proglycem
-
Nesiritide
- Direct Vasodilator
- Natrecor
-
General Effects Endothelin Antagonists??
- TX: Pulmonary hypertension
- Causes decrease in vasoconstriction and proliferation of smooth muscle
-
Bosentan
- Endothelin Antagonist
- Selective for Type A and Type B Receptor
- Tracleer
-
Ambrisentan
- Endothelin Antagonist
- Selective for Type A receptor
-
General Effects of Prostacyclin Agonists??
- TX: pulmonary hypertension
- Cause vasodilation and reduce smooth muscle proliferation
-
Epoprostenol
- Prostacyclin Agonist
- Flolan
-
Treprostinil
- Prostacyclin Agonist
- Remodulin
-
Iloprost
- Prostacyclin Agonist
- Ventavis
-
General Effects of PDE-5 Inhibitors??
- TX: Pulmonary Hypertension
- If inhibit these enzymes we increase levels of cyclic nucleotides and thus get more vasodilation
- Not as effective as prostacyclin agonists or endothelin antagonists
-
Sildenafil
- PDE-5 Inhibitor
- Revatio, Viagra
-
-
-
Papverine
PDE-5 Inhibitor
-
General Effect of PGE-1 Analogue??
- TX: Erectile Dysfunction
- Prostaglandin E-1 is a vasodilator when their receptors are activated
-
Alprostadil
- PGE-1 Analogue
- Caverject, Muse
-
General Effects of HMG-CoA Reductase Inhibitors??
- Decrease TG by decreasing hepatic synthesis of VLDL and increasing hepatic uptake of IDL and VLDL remnants.
- Increase HDL by stimulating pre-beta-HDL synthesis, stimulate CE hydrolysis and HDL maturation
-
Atorvastatin
- HMG-CoA Reductase Inhibitor
- Lipitor
-
Rosuvastatin
- HMG-CoA Reductase Inhibitor
- Crestor
-
Pravastatin
- HMG-CoA Reductase Inhibitor
- Pravachol
-
Simvastatin
- HMG-CoA Reductase Inhibitor
- Zocor
-
Fluvastatin
- HMG-CoA Reductase Inhibitor
- Lescol
-
Lovastatin
- HMG-CoA Reductase Inhibitor
- Mevacor
-
General Effects of Bile Acid Sequestrants??
- TX: Decrease Serum LDL levels in dyslipidemia
- Positively charged resins bind to negative charges on bile acids and prevent their absorption (resins are NOT absorbed)
-
Cholestyramine
- Bile Acid Sequestrants
- Questran
-
Colestipol
- Bile Acid Sequestrants
- Colestid
-
Colesevalem
- Bile Acid Sequestrants
- Welchol
-
General Effects of Fibrates??
- TX: hypertriglyceridemia and mixed hyperlipidemia, and metabolic syndrome
- Reduce TG and increase circulating HDL
-
-
-
Niacin
- TX: hypertriglyceridemia, dyslipidemia in combo with other drugs
- Niaspan
- Decrease VLDL, Decrease LDL, Increase HDL half life and decrease TG
-
General Effects of Cholesterol Absorption Inhibitors??
- TX: dyslipidemia
- Decrease cholesterol absorption from small intestine, increase hepatic LDL receptor expression, increase gene expression of HMGCo-A reductase
-
Ezetimibe
- Cholesterol Absorption Inhibitor
- Zetia
-
Milrinone
- PDE-3 Inhibitor
- Ionotropic
- Primacor
-
Inamrinone
- PDE-3 Inhibitor
- Ionotropic
-
Digoxin
- Na/K Pump Inhibitor
- Ionotropic (vagal effect so may be used as anti-arrhythmic)
- Lanoxin
-
Digibind
- Digoxin Toxicity Antidote
- Slow Tissue Effects
- Digoxin Immune Fab
-
Adenosine
- Anti-arrhythmic
- Reduces activity of SLOW conduction tissue
- Adenocard;Adenoscan
-
Quinidine
- Anti-arrhythmic: Class 1 A
- Na Channel Blocker (Fast Tissue)
-
Procainamide
- Anti-arrhythmic: Class 1 A
- Na Channel Blocker (Fast Tissue)
-
Disopyramide
- Anti-arrhythmic: Class 1 A
- Na Channel Blocker (Fast Tissue)
- Norpace; Norpace CR
-
Lidocaine
- Anti-arrhythmic: Class 1B
- Na Channel Blocker (Fast Tissue)
- Xylocaine
-
Mexilitene
- Anti-arrhythmic: Class 1 B
- Na Channel Blocker (Fast Tissue)
-
Flecainide
- Anti-arrhythmic: Class 1 C
- Na Channel Blocker (Fast Tissue)
- Tambocor
-
Propafenone
- Anti-arrhythmic: Class 1 C
- Na Channel Blocker (Fast Tissue)
- Rythmol;Rythmol SR
-
Ibutilide
- Anti-arrhythmic: Class 3
- K Channel Blocker
- Corvert
-
Sotalol
- Anti-arrhythmic: Class 3
- K Channel Blocker
- Betapace
-
Dofetilide
- Anti-arrhythmic: Class 3
- K Channel Blocker
- Tikosyn
-
Amiodarone
- Anti-arrhythmic: Class 3
- K Channel Blocker
- Cordarone;Pacerone
-
Dronadarone
- Anti-arrhythmic: Class 3
- K Channel Blocker
- Multaq
-
Class 2 Vaughn Williams
- Anti-arrhythmics: Beta-Blockers
- Slow Tissue Effects
- Acebutolol (Sectral)
- Atenolol (Tenormin)
- Betaxolol (Kerlone)
- Bisoprolol (Zebeta)
- Carvedilol (Coreg)
- Esmolol (Brevibloc)
- Labetalol (Trandate)
- Levobunalol (Betagan)
- Nadolol (Corgard)
- Nebivolol (Bystolic)
- Pindolol (Visken)
- Propranolol (Inderal)
- Metoprolol (Toprol;Lopressor)
- Sotalol (Betapace)
-
Class 4 Vaughn Williams
- Anti-arrhythmic: Ca Channel Blockers
- Slow Tissue Effects
- Verapamil
- Blocks L-type Ca Channels to reduce Ca entry
- Decrease late pacemaker current
- Decrease SA firing, AV conduction
- Increase action potential duration
- Increase refractory period of AV node
-
General Effects of K Channel Blockers?
- Block the delayed rectifier current
- Prolong the action potential
- Increase the refractory period of Fast Tissue
- Do NOT decrease conduction
- No inhibition of Na Channels
- Increase Ca entry which may lead to Torsades de Pointes in 10% of patients
-
General Effects of Na Channel Blockers?
- Higher affinity for open and inactivated Na Channels
- Lower affinity for resting state so will dissociate from channels in resting state
- Use Dependent block properties wherein those channels used more often will develop more block
-
General Effects of PDE-3 Inhibitors
- Raise levels of cAMP
- Increase in heart muscle contraction
- *increased levels of cyclic nucleotides may lead to arrhythmias
-
Aspirin
- Anti-platelet Drug
- Inhibits IRREVERSIBLY cycloxygenase
-
Ticlopidine
- Anti-platelet Drug
- P2Y12 Receptor Antagonist (Block ADP from binding)
- Ticlid
-
Clopidogrel
- Anti-platelet Drug
- P2Y12 Receptor Antagonist (Block ADP from binding)
- Plavix
-
Prasugrel
- Anti-platelet Drug
- P2Y12 Receptor Antagonist (Block ADP from binding)
- Effient
-
Abciximab
- Anti-platelet Drug
- GP2B/3A Antagonist (stops fibrinogen cross-linkage)
- IRREVERSIBLY binds
- Reopro
-
Tirofiban
- Anti-platelet Drug
- GP2B/3A Antagonist (stops fibrinogen cross-linkage)
- REVERSIBLY binds
- Aggrastat
-
Eptifibatide
- Anti-platelet Drug
- GP2B/3A Antagonist (stops fibrinogen cross-linkage)
- REVERSIBLY binds
- Integrilin
-
Dipyridamole
- Anti-platelet Drug
- Increases cAMP
- PDE-3 Inhibitor
- Reduces up-take of adenosine by RBC
-
Cilostazol
- Anti-platelet Drug
- PDE-3 Inhibitor
-
Pentoxyfiline
- Anti-platelet Drug (sorta...)
- Changes the shape of RBC to allow for easier movement in thrombotic vessels
-
Anagrelide
- Anti-platelet Drug
- Inhibits maturation of megakaryocytes into platelets i.e. inhibits platelet formation
-
-
Lovenox (Enoxaparin)
- Anti-Coagulant
- LMW Heparins
-
Fragmin
- Anti-Coagulant
- LMW Heparins
-
Innohep
- Anti-Coagulant
- LMW Heparins
-
Fondaparinox
- Anti-Coagulant
- Factor Xa Inhibitor
- Arixtra
-
Desirudin
- Anti-Coagulant
- Thrombin (Factor IIa) Inhibitor
-
Lepirudin
- Anti-Coagulant
- Thrombin (Factor IIa) Inhibitor
-
Bivalirudin
- Anti-Coagulant
- Thrombin (Factor IIa) Inhibitor
-
Argatroban
- Anti-Coagulant
- Thrombin (Factor IIa) Inhibitor
-
Dabigatran
- Anti-Coagulant
- Thrombin (Factor IIa) Inhibitor
- Pradaxa
-
Warfarin
- Anti-Coagulant
- Reduces synthesis of Factors II, VII, IX, X by blocking Vitamin K Reductase
- Coumadin
-
Xigris
- Anti-Coagulant
- Recombinant Activated Protein C
- TX: Sepsis
-
Streptokinase
Thrombolytic/Fibrinolytic Drug
-
Urokinase
Thrombolytic/Fibrinolytic Drug
-
Activase
- Thrombolytic/Fibrinolytic Drugs:
- Tissue Plasminogen Activator
-
Retavase
Thrombolytic/Fibrinolytic Drugs:Tissue Plasminogen Activator
-
TNKase
Thrombolytic/Fibrinolytic Drugs:Tissue Plasminogen Activator
-
-
Diflunisal
- COX Inhibitor: Non-acetylated salicylates
- Dolobid
-
Salsalate
- COX Inhibitor: Non-acetylated salicylates
- Disalcid
-
Choline Magnesium Trisalicylate
- COX Inhibitor: Non-acetylated salicylates
- Trilisate
-
Diclofenac
- COX Inhibitor: NSAIDs
- Voltaren, Cataflam
-
Etodolac
- COX Inhibitor: NSAIDs
- Lodine
-
Fenoprofen
- COX Inhibitor: NSAIDs
- Nalfon
-
Flurbiprofen
- COX Inhibitor: NSAIDs
- Ansaid
-
Ibuprofen
- COX Inhibitor: NSAIDs
- Motrin
-
Indomethacin
- COX Inhibitor: NSAIDs
- Indocin
-
Ketoprofen
- COX Inhibitor: NSAIDs
- Orudis
-
Ketorolac
- COX Inhibitor: NSAIDs
- Toradol
-
Meloxicam
- COX Inhibitor: NSAIDs
- Mobic
-
Mefenamic Acid
- COX Inhibitor: NSAIDs
- Ponstel
-
Nabumetone
- COX Inhibitor: NSAIDs
- Relafen
-
Naproxen
- COX Inhibitor: NSAIDs
- Naprosyn
-
Oxaprozin
- COX Inhibitor: NSAIDs
- Daypro
-
Piroxicam
- COX Inhibitor: NSAIDs
- Feldene
-
Sulindac
- COX Inhibitor: NSAIDs
- Clinoril
-
Tolmetin
- COX Inhibitor: NSAIDs
- Tolectin
-
General Effects of COX inhibitors??
Oerall?
- General: decrease production of TXA2, PGI-2 and PGE-2
- Overall: decrease pain, decrease hightened temperatures (aka fever) and decrease inflammation (only high dose or selective COX-2 inhibitors)
-
Celecoxib
- Selective COX-2 Inhibitor
- Celebrex
-
-
Zafirlukast
- Leukotriene Receptor Antagonist
- Accolate
-
Montelukast
- Leukotriene Receptor Antagonist
- Singulair
-
Zileuton
- 5-lipoxygenase Inhibitor
- Zyflo CR
-
-
Allopurinol
- Anti-Gout: Xantine Oxidase Inhibitor
- Zyloprim, Aloprim
-
Feboxustat
Anti-Gout: Xanthine Oxidase Inhibitor
-
Probenecid
Anti-Gout: Uricosuric
-
Sulfinpyrazone
Anti-Gout: Uricosuric
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