MED-Mark 1 Kit

Atropine: parasympatholytic

Pralidoxime chloride: cholinesterase reactivator

• Atropine counters parasympathetic response from muscarinic receptor over-stimulation associated with organophosphate and nerve agent poisoning
• Pralidoxime chloride reactivates acetylcholinesterase by binding to it and subsequently releasing the phosphoryl group associated with the poisoning

Organophosphate and nerve agent poisonings in MCIs

None in emergency setting

• No prophylactic protection, only administer if s/s present
• Do not treat fasiculations caused by nicotinic receptor over-stimulation

• Dry mouth
• Flushing
• Pupil dilation
• Tachycardia

• Contains:
• Atropine 2 mg
• Pralidoxime chloride 600 mg

Minor symptoms initially: One Mark 1 Kit autoinjector

If severe symptoms set in within 10 mins of first dose: Two Mark 1 Kits autoinjectors

• If severe symptoms present initially:
• Three Mark 1 Kits

Tube one (atropine) is always administered first

Diazepam is drug of choice for fasiculations