-
Insuling Lispro
- Short Duration, Rapid Acting
- Onset: 15 - 30 min
- Peak: 30 - 2.5 hr
- Dur: 3 - 6.5 hr
- with meals for postprandial ↑BG
- used concurrently with others
-
Regular Insulin
- Short Duration, Slower Acting
- onset: 30 - 60 min
- peak: 60m - 5 hr
- duration: 6 - 10 hr
- 30 min ac
-
NPH Insulin
- Intermediate Duration
- onset: 60 - 120 min
- peak: 6 - 14 hr
- duration: 16 - 24 hr
- control btwn meals & @night
- č or š food
- Protamine Allergy?
- Cloudy
- Mixable
-
Insulin Glargine [Lantus]
- Long Duration
- onset: 70 min
- peak: none!
- duration: 24 hrs
- steady control over 24 hrs
- same time each day
- usually @ hs č snack
- do not mix
-
Glucotrol
- (like "oral insulin")
- Sulfonylurea (Glipizide)
- works in pancreas
- ↑ insulin production
- ↑ insulin response
- with food, no alcohol
-
Repaglinide [Prandin]
- Meglitinide (Glinide)
- like Sulfonylureas ("Glipizide, like "Glinide")
- works in pancreas
- ↑ insulin secretion
- within 30 min of meals
-
Metformin [Glucophage, Glumetza, Foramet, Riomet]
- Biguanide ("B" for "Bedtime")
- works in liver
- ↓ glucose production
- ↑ insulin response
- ↓ basal and postprandial BG
- (also good for those who skip meals)
- ae: Lactic Acidosis
- Take at night to ↑ absorption
-
Rosiglitazone
- Glitazones
- R: insulin: ↑ response, ↓ resistance
- Gl: Glucose: ↑ uptake, ↓ production
- ae: Fluid Retention, ↑ Cholesterol
- (avoid with HF)
-
Acarbose [Precose]
- α-Glucosidase Inhibitor
- "Blocks the Carbs, Precursor to GAS"
- ↓ carb digestion/absorption
- ↓ postprandial BG
- ↓ HgA1c
- ae: Gas (GI distress), Liver Dysfxn (with long-term use)
- with first bite of meal
-
Glucagon
Antidote: Insulin Overdose
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