1. What does Site-specific chemical delivery require?
    Prodrug reaches the target site and then enzymatic or chemical processes exist at the target site to release the active drug
  2. Factors Involved with Successful Site-Specific Drug Delivery:
    • Extent of target organ perfusion
    • Rate of conversion of prodrug to active drug
    • Input/output rates of prodrug and drug from the target sites
  3. Additional Carrier Systems Evaluated for Drug Delivery
    • Proteins
    • Polysaccharides
    • Liposomes
    • Emulsions- oil and water
    • Cellular carriers (rbc/wbc)
    • Magnetic controlled targeting
    • Implanted mechanical pumps
  4. Understand what constitutes a polymeric drug complex
    • Prodrug must be readily transported to the site of action and rapidly absorbed at the site
    • Upon arrival at the target site, the prodrug should be selectively converted to (active compoent) drug relative to its rate of conversion at nontarget sites
  5. Distinguish between a polymeric drug complex and a targeted polymeric drug complex
    Advantages and disadvantages
  6. Types of polymers used to develop a polymeric drug complex (PEG, micelles, dendrimers)
  7. Describe advantages and disadvantages between systems (ex. drug carrying capacity)
  8. Understand the means of linker cleavage
    –Chemical/enzymes, pH, and light
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