Unit11PolymericDrugComplexesDelivery

What does Site-specific chemical delivery require?

Prodrug reaches the target site and then enzymatic or chemical processes exist at the target site to release the active drug
Factors Involved with Successful Site-Specific Drug Delivery:
- Extent of target organ perfusion
- Rate of conversion of prodrug to active drug
- Input/output rates of prodrug and drug from the target sites
Additional Carrier Systems Evaluated for Drug Delivery
- Proteins
- Polysaccharides
- Liposomes
- Emulsions- oil and water
- Cellular carriers (rbc/wbc)
- Magnetic controlled targeting
- Implanted mechanical pumps
Understand what constitutes a polymeric drug complex
- Prodrug must be readily transported to the site of action and rapidly absorbed at the site
- Upon arrival at the target site, the prodrug should be selectively converted to (active compoent) drug relative to its rate of conversion at nontarget sites
Distinguish between a polymeric drug complex and a targeted polymeric drug complex
Advantages and disadvantages
Types of polymers used to develop a polymeric drug complex (PEG, micelles, dendrimers)
Describe advantages and disadvantages between systems (ex. drug carrying capacity)
Understand the means of linker cleavage
–Chemical/enzymes, pH, and light

Author

pebbles135

53546

Card Set

Unit11PolymericDrugComplexesDelivery

Description

PharmaceuticsBlock4

Updated

2010-12-05T23:22:45Z

Show Answers