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Antimicrobial Drugs:
Chemotherapy
: the use of drugs to treat a disease
Antimicrobial drugs
: interfere with the growth of microbes within a host
-cidal vs. -static
Bactericidal
-kills microbes directly
Bacteriostatic
-prevents microbes from growing
Action of Antimicrobial Drugs:
cell wall synthesis
protein synthesis
nucleic acid replication
plasma membrane
essential metabolites
An Antimicrobial: Cell Wall Synthesis Inhibitors
Bacitracin
Carbapenems
Cephalosporins
Penicillins
-inhibits cross-bridge formation
-cell wall doesn't form; cell lysis occurs
-cells must be actively growing
Vancomycin
An Antimicrobial: Protein Synthesis Inhibitors
yields cell death
Chloramphenicol
Tetracycline
Streptomycin
An Antimicrobial: Nucleic Acid Replication
Rifamycin
-inhibits RNA synthesis
Quinolones
ex
:
Cipro
-inhibits DNA replication
An Antimicrobial: Plasma Membrane
Polymyxin B
-Topical application only
-destroys cell membranes in bacteria and eukaryotes
-combined with
bacitracin
&
neomycin
in
Neosporin
An Antimicrobial: Metabolite Analogs
Sulfonamindes
-aka
: sulfa drugs
-inhibits folic acid systhesis
-bacteria must synthesize folic acid
-broad spectrum
Bacteria have different sensitivities
Tests for sensitivity
-
disk diffusion
-
E test
--MIC
-
broth dilution test
Antibiotic Resistance
Microbes can become resistant to antibiotics:
-enzyme destruction of drug
-prevention of penetration of drug
-alteration of drug's target site
-rapid ejection of the drug
Author
aliceaustin
ID
53320
Card Set
Microbiology
Description
Antimicrobial Drugs
Updated
2011-08-04T01:39:11Z
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