MCB 62 LSD and Mescaline

1897 isolated mescaline from peyote cactus

• Brand name for LSD, made by Sandoz and distributed free of charge for research
• 1950s
• suggested psychiatrists take it to understand their mental patients better

• 1950s-1960s there was clinical research using LSD for the treatment of addiction, psychosis, and other mental illnesses
• Bill Wilson, founder of AA, had experienced this

1950S government looked into possible chemical weapon use

• wrote "The Doors of Perception"
• helped name "psychedelics"

• PHD from Berkeley
• Nixon called him the "most dangerous man in America"
• psychologist that encouraged LSD useage

• LSD maker in Berkeley
• Gave away LSD free or low cost in the Bay Area in the 60s, contributed to its popularity

• 1970s introduced
• paper with small squares of LSD, perfect portions

• known physical toxicity is low to nonexistant
• therapeutic index is very high
• dangerous behavior while intoxicared possible
• anxiety and panic associated with a bad trip
• creation or exacerbating of long term cognitive/emotional problems

re-experiencing altered state in absence of the drug

• late 1960s laws against LSD in some states including California
• 1968 CSA Schedule 1

agonist @ serotonin 2A receptors

• psychedelic mushroom containing psilocybin and related molecules
• psilocybin and psilocin are the active chemicals
• Identified by Albert Hoffman in 1958

• oaxaca, mexico in the 1950s
• found ritual mushroom usage by the mazatecs
• techanacatl= aztec name meaning "flesh of the gods"

mazatec shaman who introduced the modern world to the ritual ehtnobotanical uses of mushrooms in her culture