MCB 62 Cocaine and Psychadelics

  1. Coca Cola
    • started as an alternative to coca wine, wanted a coca drink without alcohol
    • coca= cocaine cola=caffeine
    • cocaine removed in 1903
  2. Calcium carbonate and coca powder
    • cocaine hydrochloride salt is water soluble
    • mix with calcium carbonate removes H+ making it easier to absorb orally
  3. Cocaine Addiction Potential
    • HIGH
    • blocks dopamine and norepinephrine reuptake transporters
  4. Routes of cocaine entry
    • All
    • More toxic effects from: snorting, injecting, smoking
    • Can OD from body packing
  5. Different names for Psychedelics
    • Aldous Huxley and H.Osmond sent letters back and forth
    • Osmond made up word psychadelic (mind revealing)
    • psyche=spirit
    • deloun=to show, manigest
    • medical papers still tend to use the word hallucinogen
  6. Schultes
    wrote "Plants of the Gods"
  7. Effects of Psychedelics on the mind
    • heightened awareness of external sensory inputs (visual, auditory, tactile, and internal thoughts and feelings)
    • increased emotional quality to stimuli
    • distortion of sensory perceptions (hallucinations)
    • loosening of psychological defenses
    • unconscious material comes into awareness (beneficial for therapy, may cause panic)
    • varies powerfully by set and settting
    • varies by dose
  8. LSD (Lysergic Acid Diethylmide)
    • Schedule 1
    • derivative of ergotamine in ergot fungus
    • most potent psychoactive chemical derived from a natural product
  9. Albert Hoffman
    • synthesized LSD in 1938 and again in 1945
    • landmark event in neurochemistry
    • wrote down effects in journal
    • ergotamine in plant--->LSD
  10. Typical doses
    • threshold does ~10 micrograms
    • typical psychedelic dose 40-400 micrograms
    • current street illict dose ~65 micrograms
Card Set
MCB 62 Cocaine and Psychadelics
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