-
Coca Cola
- started as an alternative to coca wine, wanted a coca drink without alcohol
- coca= cocaine cola=caffeine
- cocaine removed in 1903
-
Calcium carbonate and coca powder
- cocaine hydrochloride salt is water soluble
- mix with calcium carbonate removes H+ making it easier to absorb orally
-
Cocaine Addiction Potential
- HIGH
- blocks dopamine and norepinephrine reuptake transporters
-
Routes of cocaine entry
- All
- More toxic effects from: snorting, injecting, smoking
- Can OD from body packing
-
Different names for Psychedelics
- Aldous Huxley and H.Osmond sent letters back and forth
- Osmond made up word psychadelic (mind revealing)
- psyche=spirit
- deloun=to show, manigest
- medical papers still tend to use the word hallucinogen
-
Schultes
wrote "Plants of the Gods"
-
Effects of Psychedelics on the mind
- heightened awareness of external sensory inputs (visual, auditory, tactile, and internal thoughts and feelings)
- increased emotional quality to stimuli
- distortion of sensory perceptions (hallucinations)
- loosening of psychological defenses
- unconscious material comes into awareness (beneficial for therapy, may cause panic)
- varies powerfully by set and settting
- varies by dose
-
LSD (Lysergic Acid Diethylmide)
- Schedule 1
- derivative of ergotamine in ergot fungus
- most potent psychoactive chemical derived from a natural product
-
Albert Hoffman
- synthesized LSD in 1938 and again in 1945
- landmark event in neurochemistry
- wrote down effects in journal
- ergotamine in plant--->LSD
-
Typical doses
- threshold does ~10 micrograms
- typical psychedelic dose 40-400 micrograms
- current street illict dose ~65 micrograms
|
|
