anti-seizure meds

  1. Phenytoin (Dilantin)
    • -for ALL types EXCEPT abscence
    • -given PO or IV w/ NS only
    • -900-1500 mg IV infused at 50mg/min max (too fast of infusion = heart probs)
    • -watch for bradycardia, and heart block, hypotension
    • -can cause ataxia, dizziness, may decr. WBC, RBC, and granulocyte count, may cause gingival hyperplasia
  2. Fosphenytoin (Cerebyx)
    • -for ALL types EXCEPT absence
    • -15-20mgPE/kg IV at 100-150 mPE/min (can be given more rapidly than Dilantin)
    • -mix in NS or dextrose slns, dilute to 25 mgPE/ml
    • -can admin IM, cannot admin PO
  3. Carbamazepine (Tegretol)
    • -primary tx for generalized and complex partial
    • -monitor for diplopia, GI upset, hepatic dysfunction and blood dyscrasia (blood disease)
  4. Clonazepam (Klonopin)
    • -for absence
    • -monitor behavioral changes, drowsiness, ataxia
  5. Diazepam (Valium)
    • -for status epilepticus (prferred drug)
    • -inject 5-20mg direct IV push d/t incompatibilities w/ all other IVF
    • -give in most proximal port possible
  6. Lorazepam (Ativan)
    • -for status epilepticus (preferred drug)
    • -inject 2-4mg diluted in equal volume sterile water over 2 min; may repeat up to 8mg total
  7. Valproic acid (Depakene)
    Divalproex (Depakote)
    • -for all types
    • -monitor for hepatotoxicity, N/V, thrombocytopenia, hair loss
  8. Gabapentin (Neurontin)
    • -adjunct therapy for partial seizures incl. secondary generalized seizures
    • -monitor somnolence, fatigue, ataxia, dyspnea
  9. Phenobarbitol (Luminol)
    • -partial or generalized status elipepticus
    • -a barbiturate
    • -monitor for hangover, sedation, laryngospasm, angioedema and serum sickness
  10. Lamotrigine (Lamictal)
    • -partial seizures
    • -watch for diplopia, HA, ataxia
    • -life threatening ig given w/ Valproic acid (Depakene)
Card Set
anti-seizure meds
exam 3 neuro