the study of the effects of ionizing radiation on living tissue
radiation biology
T or F. in diagnostic radiography, not all x-rays pass through the patient and reach the dental x-ray film; some are absorbed by patient tissues
true
the total transfer of energy from the x ray photon to the pt tissues
absorption
what happens when x-ray energy is absorbed by pt tissues?
chemical changes occur that result in biologic damage
What are 2 specific mechanisms of radiation injury?
ionization
free radical formation
x-rays are a form of________ radiation, when x rays strike patients tissues,_______results
ionizing
ionization
what is produced throught he photoelectric effect, or compton scatter, and results in the formation of a positive atom and a dislodged negative electron?
ionization
forms a positive atom and a dislodged negative electron
ionization
Ionization caus____ ______in the cell that results in biological damage
chemical changes
Ionization causes chemical changes in the cell that results in ____ _______
biological damage
X radiation causes cell damage primarily through formation in which type of radiation injury?
free radical formation
occurs when an x ray photon ionizes water
free radical formation
What is the primary component of living cells?
water
Ionization of water results in the production of_____ and____ _____ ____
hydrogen
hydroxyl free radicals
an uncharged (neutral) atom or molecule that exists with a single, unpaired electron in its outermost shell
free radical
true or false. a free radical is highly reactive and unstable
true
What are 3 ways that free radicals can achieve stability?
recombine without changes in the molecule
combine with ordinary molecules and form a toxin (hydrogen peroxide) capable of producing widespread cellular changes
combine with other free radicals and cause change
What toxin s formed when a free radical combines with ordinary molecules and forms a toxin?
hydrogen peroxide
Damage to living tissues due to exposure to ionizing radiation may result from what 2 things?
direct hit and absorption of an x-ray photon within a cell
absorption of an x-ray photon by water within a cell accompanied by free radical formation
What are the 2 theories about how radiation damages bioligic tissues?
direct
indirect
suggests that cell damage results when ionizing radiation directly hits critical areas whtin the cell
direct theory
What is an example of a critical area in the cell in the direct theory?
DNA
Do direct injuries from exposure toionizing radiation occur frequently or infrequently?
infrequently, most x ray photons pass through the cell and cause little or no damage
suggests the x-ray photons are absorbed within the cell and cause the formation of toxins, which in turn damage the cell
indirect theory
when x-ray photons are absorbed by water within a cell ___ ____ _______ results
free
radical
formation
In the indirect theory the free radicals combine to form_____ which cause cellular dysfunction and_______ _______
toxins (H2O2)
biologic damage
an indirect injury results because the _____ ______ combine and form ______
free radicals
toxins
Why is the chance of free radical formation and indirect injury treat?
because cells are composed of 70-80% water
used to correlate the 'response' or damage, of tissues with the 'dose' or amount, of radiation recieved
dose-response curve
When dose and damage are plotted on a graph, a______, ________ relationship is seen
linear
nonthreshold
indicates tat the response of the tissues is directly proportional to the dose
linear
indicates that a threshold dose level for damage does not exist, suggests that no matter how small the amount of radiation recieved, some damage occurs
nonthreshold
Is there a safe amount of radiation exposure?
NO!
Biologic effects from radiation can be classified as what 2 types?
stochastic
nonstochastic
______ effects occur as a direct function of dose
stochastic
In what effect does the probability of occurrence increase with increasing absorbed dose; however, the severity of effects does not depend on the magnitude of the absorbed dose?
stochastic effect
true or false. stochastic effects do not have a dose threshold
true
What are 2 examples of stochastic effects?
cancer (tumor) induction
genetic mutations
What is another name for nonstochastic effects?
deterministic effects
somatic effects that have a threshold and increase in severity with increasing absorbed dose
nonstochastic (deterministic) effects
What are 4 examples of nonstochastic effects?
erythema
loss of hair
cataract formation
decreased fertility
Which biologic effect requires more radiation doses to seriously impair health?
nonstochastic
chemical reactions (ionization, free radical formation) that follow the absorption of radiation occur rapidly at the______ _______
molecular level
varying amounts of time are required for chemical reaction (ionization, free radical formation) changes to alter____ and _____ _______
cells
cellular functions
true or false. the observable effects of radiation are not visible immediately after exposure
true
the time that elapses between exposure to ionizing radiation and the appearance of observable clinical signs
latent period
The latent period may be short or long depending on what 2 things?
total dose of radiation recieved
amount of time, or rate it took to recieve the dose
The more radiation recieved, and the faster the dose rate, the_________the latent period
shorter
cell death, changes in cell function, breaking or clumping of chromosomes, formation of giant cells, cessateion of mitotic activity, or abnormal mitotic activity are all examples of what?
period of injury
What is the last event in the sequence of radiation injury?
recovery period
What is the order of the radiatio injury sequence?
latent period - period of injury - recovery period
true or false. all cellular radiation injuries are permanent
FALSE!!!
with each radiation exposure, cellulear damage is followed by____
repair
Most of the damage caused by _______ radiation is repaired with cells of the body.
low-level
effects of radiaion exposure are additive and damage that remains unrepaired accumulates in the tissues, is termed:
cumulateive effects
____________ of repeated radiation exposure can lead to health problems.
cumulative effects
Radiation effect on hematopoietic (blood forming):
leukemia
radiation effects on reprocuctive (ova, sperm)
mutations
radiation effects on thyroid
carcinoma
radiation effects on skin
carcinoma
radiation effects on eyes
cataracts
Name 5 factors that influence radiation injury:
total dose
dose rate
amount of tissue irradiated
cell sensitivity
age
the quantity of radiation received, or the total amount of radiation energy absorbed
total dose
the rate at which exposure to radiation occurs and absorption takes place
dose rate
dose rate = _______
dose/time
Why does more radiation damage take place with high dose rates?
because a rapid delivery o radiation does not allow time for the cellular damage to be repaired
the areoas of the body exposed to radiation
amount of tissue irradiated
What is an example of total body irradiation?
a person exposed to a nuclear energy disaster
extensive radiation injury occurs when large areas of the body are exposed because of the damage that occurs to the______ _________ _________
blood forming tissues
true or false. cell sensitivity affects radiation injury
true
are children or adults more susceptible to radiation damage?