Pathogenic Micro.txt

• political commitment with increasing in finance
• case detection through quality microscopy
• standard treatment
• affective drug supply
• monitoring system

• survives and replicates within macrophages
• persist in lungs for decades
• has developed to manipulate infected cell in many ways

• slowe onset
• weight loss
• lung tissue dirstuction

• rare pediatric disease
• can result in meningitis

• member of Mtb
• can't be cultured in vitro
• armadilo is only host beside human
• cause of chronic cellular disease

initial bacteria replication in macrophage and later spread to peripheral nerves and subsequent sensory impairment.

• endemic in india,brazil,nepal and myanmar
• 700000 new cases in 2002
• spread by person to person
• strong genetic component

• Acid fast seen in lesions
• leproumin test which only detects tuberculoid leprosey
• PCR on tissue sample

• Rifampin/dapsone ( antimetabolite, folic acid biosyntethis ) > 6-24 M
• BCG vaccine

• >M.avium complex/M.interacellular/M.paratuberculosis
• >M. kansasii

• environmental source
• infection caused by inhalation/injection
• major pathogen in immunocomprimized

• pulmonary infection in patients with pre.existing lung condition
• dissemination infections in immunodeficient patients ( increase bacterial burden in tissue and blood)

• cause of inflamatory bowl disease in sheep and cattle ( john's disease)
• it is suspected to casue similar disease in human ( crohn's disease)
• extremely fastodious and slow growth

• Same as Mtb
• However differential diagnosis is a challange because NTM are very similar
• use of specific nucleotide probe

• It is drug resistant
• clarithromycin/ethambutol and rifabutin for 9 month
• success of treatment and tolerance of patient to treatment must be mentioned

INH/ Rifampin and ethambutol for 9 month