what are some strategy for DOT treatment?
political commitment with increasing in finance
case detection through quality microscopy
affective drug supply
what are some characteristics of Mtb?
survives and replicates within macrophages
persist in lungs for decades
has developed to manipulate infected cell in many ways
what are some signs associated with pulmonary TB?
lung tissue dirstuction
what are some signs associated with Diseminated TB?
rare pediatric disease
can result in meningitis
what are some characteristics associated with M.leprae?
member of Mtb
can't be cultured in vitro
armadilo is only host beside human
cause of chronic cellular disease
what is the route associated with Hansen diseas/leprosey?
initial bacteria replication in macrophage and later spread to peripheral nerves and subsequent sensory impairment.
what are some epidemiological factors associated with M.leprea?
endemic in india,brazil,nepal and myanmar
700000 new cases in 2002
spread by person to person
strong genetic component
what are some diagnostic ways for M.leprae?
Acid fast seen in lesions
leproumin test which only detects tuberculoid leprosey
PCR on tissue sample
what are some treatments suggested for M.lepreae?
Rifampin/dapsone ( antimetabolite, folic acid biosyntethis ) > 6-24 M
what are some Non Tb mycobacteria?
what are some epidemiological factor assosiated with NTM?
infection caused by inhalation/injection
major pathogen in immunocomprimized
what are some clinical manifestation for M.avium ?interacellular and kansaii?
pulmonary infection in patients with pre.existing lung condition
dissemination infections in immunodeficient patients ( increase bacterial burden in tissue and blood)
what are some clinical manifestation for M.paratuberculosis ?
cause of inflamatory bowl disease in sheep and cattle ( john's disease)
it is suspected to casue similar disease in human ( crohn's disease)
extremely fastodious and slow growth
what are some diagnostic tools for NTM?
Same as Mtb
However differential diagnosis is a challange because NTM are very similar
use of specific nucleotide probe
what are some treatments available for M.avium complex?
It is drug resistant
clarithromycin/ethambutol and rifabutin for 9 month
success of treatment and tolerance of patient to treatment must be mentioned
what are some treatments available for M.kansasii?
INH/ Rifampin and ethambutol for 9 month