Introduction to Forensic Toxicology

  1. What is toxicology?
    It encompasses the measurement of alcohol, drugs, and other toxic substance in biological specimens and interpretation of such results in a medico legal context.
  2. Name some examples of specimens sent to a toxicology lab.
    • blood
    • urine
    • vitreous humor
    • bile
    • gastric contents
    • tissues (eg liver)
    • decomposition fluid
    • all hospital samples
  3. Volatiles, EMIT, DOA, GC/MS, and CO-oximetry/Conway diffusion are all examples of ______ ______.
    screening analyses
  4. Volatile analysis by HS-GC detects what four substances?
    isopropanol, ethanol, methanol, acetone
  5. HS-GC is mainly performed on ______ and ______.
    blood and vitreous
  6. T/F: All positive samples with HS-GC are tested twice to ensure results correlate.
    True!! But only the lower value is reported.
  7. What does EMIT stand for and what types of samples would you test with it?
    Enzyme Multiplied Immunoassay Technique

    Urine samples only
  8. What does ELISA stand for and what types of samples do you test with it?
    Enzyme Linked Immunoassay Assay

    blood, vitreous, serum/plasma, tissue homogenates
  9. ATOX is what kind of drug extraction?
    acidic/ neutral
  10. BTOX is what type of drug extraction?
    basic neutral
  11. What does CO-oximetry screen?
    blood for carbon monoxide
  12. The presence of carboxyhemoglobin is confirmed by which test?
    Conway Microdiffusion
  13. What reagent is in the center well in a conway microdiffusion plate?
    palladium chloride
  14. What two things are in the conway microdiffusion outer ring?
    blood mixed with acetic acid
  15. Vitreous chemistry tests detect the presence of what components?
    sodium, chlorine, glucose, urea nitrogen, potassium
  16. T/F: Vitreous chemistry can indicate signs of dehydration/
  17. Most toxicology assays achieve confirmation without ______.
Card Set
Introduction to Forensic Toxicology
Forensic Toxicology