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The study of the molecular basis of genes and gene expression; molecular genetics
Molecular Biology
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A virus that infects bacteria; also called a phage
Bacteriophage (phage)
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An organic monomer consisting of a five-carbon sugar covalently bonded to a nitrogenous base and a phosphate group. -----s are the building blocks of nucleic acid
Nucleotide
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A polymer made up of many nucleotides covalently bonded together
Polynucleotide
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The alternating chain of of sugar and phosphate to which the DNA and RNA nitrogenous bases are attached
Sugar-Phosphate Backbone
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A single-ring nitrogenous base found in DNA
Thymine
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A single-ring nitrogenous base found in DNA and RNA
Cytosine
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A double-ring nitrogenous base found in DNA and RNA
Adenine
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A double-ring nitrogenous base found in found in DNA and RNA
Guanine
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A fluid-filled inner ear chamber containing hair cells that detect the position of the head relative to gravity
Uracil
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The form of native DNA, referring to its two adjacent polynucleotide strands wound into a spiral shape
Double Helix
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An enzyme that assembles DNA nucleotides into polynucleotides using a preexisting strand of DNA as a template
DNA Polymerase
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An enzyme essential for DNA replication that catalyzes the covalent bonding of adjacent DNA nucleotides; used in genetic engineering to paste a specific piece of DNA containing a gene of interest into a bacterial plasmid or other vector
DNA Ligase
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The synthesis of RNA on a DNA template
Transcription
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The synthesis of a polypeptide using the genetic information encoded in an mRNA molecule. There is a change of "language" from nucleotides to amino acids
Translation
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A set of three-nucleotide-long words that specify the amino acids for polypeptide chains
----or----
The set of rules giving the correspondence between nucleotide triplets (codons) in mRNA and amino acids in protein
Triplet Code
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A three-nucleotide sequence in mRNA that specifies a particular amino acid or polypeptide termination signal; the basic unit of the genetic code
Codon
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An enzyme that links together the growing chain of RNA nucleotides during transcription using a DNA strand as a template
RNA Polymerase
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A specific nucleotide sequence in DNA located at the start of a gene that is the binding site for RNA polyerase and the place where transcriptions begins
Promoter
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A special sequence of nucleotides in DNA that marks the end of a gene; it signals RNA polymerase to release the newly made RNA molecule, which departs from the gene
Terminator
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The type of ribonucleic acid that encodes genetic information from DNA and conveys it to ribosomes where the information is translated into amino acid sequences
Messenger RNA (mRNA)
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In eukaryotes, a nonexpressed (noncoding) portion of a gene that is exiced from the RNA transcript
Intron
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In eukaryotes, a coding portion of a gene
Exon
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The removal of introns and joining of exons in eukaryotic RNA, forming an mRNA molecule with a continuous coding sequence; occurs before mRNA leaves the nucleus
RNA Splicing
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A type of ribonucleic acid that functions functions as an interpreter in translation. Each tRNA molecule has a specific anti-codon, picks up a specific amino acid and conveys the amino acid to the appropriate codon on mRNA
Transfer RNA (tRNA)
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On a tRNA molecule a specific sequence of three nucleotides that is complementary to a codon triplet on mRNA
Anticodon
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The type of ribonucleic acid that together with proteins makes up ribosomes; the most abundant type of RNA
Ribosomal RNA (rRNA)
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On mRNA the specific three-nucleotide sequence (AUG) to which an initiator tRNA molecule binds, starting translation of genetic information
Start Codon
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In mRNA, one of three triplets (UAG, UAA, AGA) that signal gene translation of genetic information
Stop Codon
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A change in a chromosome resulting from a chromosomal fragment attaching to a nongomologous chromosome; can occur as a result of an error in a meiosis or from mutagenesis
Translocation
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A change in the nucleotide sequence of DNA; the ultimate source of genetic diversity
Mutation
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The way in which a cell's mRNA-translating machinery groups the mRNA nucleotides into codons
Reading Frame
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The creation of a mutation
Mutagenesis
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A chemical or physical agent that interacts with DNA and causes a mutation
Mutagen
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A type of viral replication cycle resulting in the release of new viruses by lysis (breaking open) of the host cell
Lytic Cycle
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A type of bacteriophage replication cycle in which the viral genome is incorporated into the bacterial host chromosome as a prophage; new phages are not produced and the host cell not killed or lysed unless the viral genome leaves the host chromosome
Lysogenic Cycle
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Phage DNA that has inserted by genetic recombination into the the DNA of a prokaryotic chromosome
Prophage
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An RNA virus that reproduces by means of a DNA molecule; it reverse-transcribes its RNA into DNA inserts the DNA into a cellular chromosome and then transcribes more copies of the RNA from the viral DNA. HIV and a number of cancer-causing viruses are ------s
Retrovirus
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An enzyme that catalyzes the synthesis of DNA on an RNA template
Reverse Transcriptase
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Aquirred immune deficiency syndrome; the late stages of HIV infection; characterized by a reduced number of T cells; usually results in death caused by other diseases
AIDS
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Human immunodeficiency virus the retrovirus that attacks the human immune system and causes AIDS
HIV
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