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Organic compounds such as glucose store energy in their _________. These molecules are broken down and their energy extracted in _____.
- arrangements of atoms.
- cellular respiration
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The most prevalent and efficient catabolic pathway for the production of ATP, in which oxygen is consumed as a reactant along with the organic fuel.
cellular respiration
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An organelle in eukaryotic cells that serves as the site of cellular respiration.
mitochondrion
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An organic molecule serving as a cofactor. Most vitamins function as coenzymes in important metabolic reactions.
coenzyme
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The first stage of cellular respiration occurs in the ____, while the second and third stages occur in _____.
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In cellular respiration, electrons are transferred from glucose to ____ such as ____ and finally to ____; the energy released by this relocation of electrons is used to make ____. ____and ____ are given off as byproducts.
- conezymes
- NAD+
- oxygen
- ATP
- CO2Water
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The splitting of glucose into pyruvate; one metabolic pathway that occurs in all living cells, serving as the starting point for fermentation or aerobic respiration.
glycolysis
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Glycolysis is a series of steps in which a glucose molecule is broken down into two molecules of ___.
pyruvate
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As the chemical bonds in glucose are broken, electrons (and hydrogen ions) are picked up by ___ forming ___. Glucose is oxidized and ___ is reduced.
-
A net output of __ ATP molecules are also produced in glycolysis for every glucose molecule processed. But most of the energy released by the breakdown of glucose is carried by the electrons attached to __.
-
A chemical cycle involving eight steps that completes the metabolic breakdown of glucose molecules to carbon dioxide; occurs within the mitochondrion; the second major stage in cellular respiration.
citric acid cycle
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The pyruvate molecules are modified as they enter the mitochondrion, releasing ____. The altered molecules enter a series of reactions called the _____.
- carbon dioxide
- citric acid cycle
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More carbon dioxide is released as the ___ completes the oxidation of glucose. __ ATPs are formed per glucose, but most of the energy released by the oxidation of glucose is carried by ___ and ___.
- citric acid cycle
- two
- NADH
- FADH2
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The loss of electrons from a substance involved in a redox reaction.
oxidation
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Almost all of the ATP produced by cellular respiration is banked in the final phase— ______. The NADH and FADH2 molecules produced in glycolysis and the citric acid cycle donate their electrons to the _____.
- oxidative phosphorylation
- electron transport chain
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At the end of the chain, ____ exerts a strong pull on the electrons, and combines with them and hydrogen ions (protons) to form ___.
-
The _____converts chemical energy of moving electrons to a form that can be used to drive _____, which produces about ___ ATP molecules for each glucose molecule consumed.
- electron transport chain
- oxidative phosphorylation
- 34
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___, which begins the breakdown of glucose, is a series of _______ that can be divided into _____.
- glycolysis
- ten enzyme-catalyzed chemical reactions
- two main phases
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In the ______, some ATP energy is used to start the process of _____. By the end of this phase, a __-carbon molecule (glucose) has been split into two __-carbon molecules of _______
- energy-investment phase
- glucose oxidation
- 6
- 3
- glyceraldehyde-3-phosphate.
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The formation of ATP by directly transferring a phosphate group to ADP from an intermediate substrate in catabolism.
substrate- level phosphorylation
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The 3-carbon glyceraldehyde-3-phosphate molecules now enter the ____.
energy-payoff phase
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In the _____, chemical bonds are broken, and NAD+ picks up electrons and hydrogen ions, forming NADH. The energy released is used to attach ____ groups. The phosphates are transferred to ADP, finally making some ATP. This way of making ATP is called _____.
- energy-payoff phase
- phosphate
- substrate-level phosphorylation.
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In the energy-payoff phase, a couple more reactions rearrange the atoms in the __-carbon molecules. More ATP is generated in the final reaction that yields ____. For each glucose molecule broken down during glycolysis, a net of ___ ATPs are formed, along with two ___ molecules.
-
the entry compound for the citric acid cycle in cellular respiration, formed from a fragment of pyruvate attached to a coenzyme.
acetyl CoA (acetyl coenzyme)
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The oxidation of glucose continues in the ___.
citric acid cycle
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____ molecules formed during glycolysis diffuse from the cytosol into the mitochondrion, but ____ itself does not enter the citric acid cycle.
pyruvate x2
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A reaction occurs that removes a carbon atom, releasing it in ____. Electrons are transferred to an ___ molecule, storing energy. ___ joins with the ____, forming ____.
- carbon dioxide
- NADH
- coenzyme A, or CoA
- 2- carbon fragment
- acetyl CoA
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One molecule of ___enters the citric acid cycle.
acetyl CoA
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The 2-carbon fragment of ____ attaches to the 4-carbon molecule ____ in the first reaction of the cycle. This forms ____.
- acetyl CoA
- oxaloacetate
- citrate
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In a series of steps, bonds ___ and ___. ___ carbon atoms are released, one at a time, in molecules of ____. Electrons are carried off by molecules of ___ and ____. One step produces an ATP molecule by ___. A 4-carbon ___ molecule is regenerated.
- break
- reform
- two
- carbon dioxide
- NADH
- FADH2substrate-level phosphorylation
- oxaloacetate
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Since two ____ molecules are produced for each glucose molecule broken down, a second ____enters the citric acid cycle. The same series of reactions occurs.
acetyl CoA x2
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The cell has gained ___ ATPs that can be used directly. However, most of the energy originally contained in the bonds of glucose is now carried by the ___ and ___ molecules.
-
Most of the energy harvested from organic molecules during ___ and the ___is stored in NADH and FADH2.
- glycolysis
- citric acid cycle
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NADH and FADH2 give up their high-energy electrons in the third phase of cellular respiration—____ —where most of the cell's ATP fuel is produced.
oxidative phosphorylation
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A sequence of electron carrier molecules (membrane proteins) that shuttle electrons during the redox reactions that release energy used to make ATP; an array of molecules- mostly proteins- built into the inner membrane of the mitochondria
electron transport chain
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NADH gives up its high-energy electrons to the first complex in the ____. The electrons move from one member of the chain to the next, giving up their energy as they are pulled from NADH toward highly _____. The energy given up by the flow of electrons is used to pump ___ from the mitochondrial matrix into the intermembrane space.
- electron transport chain
- electronegative oxygen
- hydrogen ions
-
___ captures the electrons in the very last step in electron transport. The last complex adds a pair of electrons to an oxygen atom and two hydrogen ions, forming ___.
-
The compartment of the mitochondrion enclosed by the inner membrane and containing enzymes and substrates for the Krebs cycle.
mitochondrial matrix
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The backed-up hydrogen ions, which have alot of ___, give up their energy when they diffuse through a special protein in the membrane called ___.
- potential energy
- ATP synthase
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As hydrogen ions flow down their concentration gradient, ____ captures their energy to make ATP. This mode of ATP production is called _____ because it is powered by the transfer of electrons to oxygen.
- ATP synthase
- oxidative phosphorylation
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Under normal conditions, almost all the ATP produced in the process of cellular respiration is manufactured by ____ and ____— about ___ ATPs for every glucose consumed.
- electron transport
- oxidative phosphorylation
- 34
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__ and ___ produce a small amount of ATP via ___, but most of the cell's ATP is made via ____, when NADH and FADH2 produced in ___ and ___ give up to oxygen the electrons obtained from organic molecules.
- Glycolysis
- the citric acid cycle
- substrate-level phosphorylation
- oxidative phosphorylation
- glycolysis
- the citric acid cycle
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All cells are able to synthesize ATP via the process of ____.
glycolysis
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In many cells, if oxygen is not present, pyruvate (pyruvic acid) is metabolized in a process called _____.
fermentation
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By oxidizing the NADH produced in glycolysis, ____ regenerates NAD+, which can take part in glycolysis once again to produce more ATP.
fermentation
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The net energy gain in fermentation is __ ATP molecules per molecule of glucose.
2
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____ complements ____ and makes it possible for ATP to be continually produced in the absence of oxygen.
-
A catabolic process that makes a limited amount of ATP from glucose without an electron transport chain and that produces a characteristic end product, such as ethyl alcohol or lactic acid.
fermentation
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There are two types of fermentation: _____ and _____
-
____, which occurs in yeast, results in the production of ethanol and carbon dioxide from the conversion of pyruvate.
Alcohol fermentation
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_____, which occurs in muscle, results in the production of lactate (lactic acid) from the conversion of pyruvate.
Lactic acid fermentation
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The reduced form of nicotinamide that is one of the products of glycolysis.
NADH
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Glycolysis produces ___, ___, and ___ .
- NADH
- ATP
- pyruvate (pyruvic acid)
-
If oxygen is not present, NADH cannot be oxidized in the ______.
electron transport chain
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Without ____, the cell would run out of NAD+, bringing glycolysis to a halt.
fermentation
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In ____, the pyruvate (pyruvic acid) from glycolysis loses one carbon in the form of ____and the product is then reduced to ___by NADH. With the formation of ___, NADH is oxidized and becomes ____.
- alcohol fermentation
- carbon dioxide
- ethanol x2
- NAD+
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With a continuous supply of NAD+, ____ can continue, producing more ATP.
glycolysis
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During _____, the NADH produced by glycolysis is oxidized, ensuring a continuous supply of NAD+ for glycolysis.
fermentation
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_____ occurs in yeast cells.
Alcohol fermentation
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In _____, the pyruvate (pyruvic acid) from glycolysis is reduced to ____ by NADH. With the formation of ____, NADH is oxidized and becomes ____.
- lactic acid fermentation
- lactate (lactic acid) x2
- NAD+
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_____ occurs in muscle cells.
Lactic acid fermentation
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