Micro Exam 3

T helper cell (CD4+ cell) – chief regulatory cell of Immune Response

T cytotoxic cell (CD8+ cell) –precursor to the CTL “killer” cell

cytotoxic T lymphocyte – the end-stage cell that hasthe ability to actively destroy non-self cells

line of lymphocytes that produce antibodies

plasma cell (not going to divide anymore)

programmed cell death

major histocompatibility complex – a cassette of genes that controls all ofadaptive immunity

• MHCI
• MHCII
• MHCIII

Genes that control ability to generate cell-mediated functions

genes that control the activation of THcells

genes that are involved in the production ofcomponents of the complement system

small peptides that allow immune cells tocommunicate with each other

• IgMa
• IgGa
• IgA
• IgEa
• IgDa

• First to appear following stimulation
• Very large pentamer (lots of binding sites) “biologicalmop”

• Longest lasting
• Most abundant
• Passes from mother to child through umbilical cord
• Principle antibody in “memory” response
• Only class to cross placenta = passive immunity

• (two forms)
• SerumIgA – monomer in blood
• SecretoryIgA – polymer in secretions
• i GI tract
• ii Respiratory tree
• iii Also passive transfer in mother’s milk

• Major role in dangerous allergic reactions
• Big role against big parasites

Early receptor on B cells