what are some gram positive rods that are in CMN group? and what are the distictive cell wall components?
the unusual cell wall component are
what is the difference in the myolic acid of the 3 bacteria in CMN group?
mycobacteria had the longest chanin and strongly acid fast
nocardia had the intermediate chain and weakly acid fast
corynebacteria has the shortest chain and not acid fast
what are the two categories that corynebacterium falls under?
pathogenic ( C.diphtheriae) non.pathogenic ( opportunistic and part of common microflora C.jeikeium )
what are some characteristics of Corynebacteria
metamprphic (methylene blue stain)
not acid fast
enhanced by Co2
ferments carbs to lactic acid
what are some pathogenic factors associated with corynebacterium
exotoxin ( result in phage conversion)
two component Toxin
potent inhibitor of protein synthesis
what are some toxin's associated with C.diphtherea
Type 3 toxin
A/b subunit toxin
.A subunit inhibits interacellular target
.b subunit mediate binding to target cell and internallization
** toxin action in C.diphtherea inactivate elongation factor 2 preventing protein sysnethis by ribsome
what are some factors involved in pathogenisis
it is localized infection to tonsils and orpharynx and spread to larynx and trachea
sypm 2.5 days
obstruction of airways
** common microflora
what media does C.diphterease reduce and what color colonies are produced?
it reduces CTA to produce black colonies
what are some diagnostic ways ?
Toxin test ( vivo test is animal ) vitro test (PCR)
how does C.diphtrea spread ? what is the host? and where is it usually localized to ?
it is transmitted by aerosal droplet, and also carried by asymptomatic carriers
and in healthy is localized to oropharynx.
what types of immunizations are present?
passive and active(toxoid)
what are some ways to treat C.diphtereae?
active passive immunization
Gram positive rod