Pharm Block 2(rproductive system #2)

• • Used for early termination of
• pregnancy
• – 90% effective in up to 49 days
• pregnancy ( morning after pills)
• - They are competative inhibitors
• – May cause severe vaginal bleeding

-Estrogen stimulates prolifeation for Implantation of embryo

- progesterone stimulates secretion to nourish the embryo until implantation.

Progestins: Reduce frequency

• – Ethinly estradiol (EE)
• – Mestranol

• – Norethindrone
• – Norgestrel
• – Levonorgestrel
• – Desogestrel
• – Etonogestrel (metabolite of desogestrel)
• – Drospirenone

• • Monophasic
• – Same amount of estrogen and progestin throughout the
• cycle

• • Biphasic and Triphasic
• – Variable amount of estrogen and progesterone in phases

• – Decrease risk of endometriosis
• – Decrease osteoporosis

• - Increase risk of venous thromboembolism
• • Smokers
• • Preexisting hypertension

• – Increase risk of cancer?
• • Breast, endometrial, cervical, ovarian, . . .
• • Older high-dose OCs
• • Newer low-dose OCs

estrogen Decreases Osteoporosis more by itself then when combined with Progensterone.


No there is no increased risk. But done use them if patient has Breast cancer or has history of it.

• -Norethindrone
• -leconorgesterol
• -medroxyprogesterone acetate

these are good for women with high risk factors (smokers)

• – Thromboembolic disease
• – Cerebrovascular disease
• – MI
• – Coronary artery disease
• – Congenital hyperlipidemia
• – Carcinoma of the breast or female reproductive tract
• – Any hormone-dependent/responsive neoplasias
• – Abnormal undiagnosed vaginal bleeding
• – Known or suspected pregnancy
• – Past or present liver tumors or impaired liver function

Flutamide, Bicalutamide, Nilutamide

Use with GnRH

Use for prostate cancer and hirsutism

• Spironolactone- it i an aldosterone antagonist with Weak androgen antagonistic effects.
• use it for Gynecomastia in men.

Fiinasstride and Dutasteride

• They Block the conversion of Testosterone to to DHT (active form).
• use to treat benign prostate hyperplasia.