When giving a patient's drug in cycles, how do we watch the bone marrow side-effect?
If the drug affects the bone marrow, it won't make neutrophils. They have a lifespan. When the existing neutrophils in the body start to die off, you can measure the drop. When they get low, stop. Since you stopped, the body can make neutrophils again. When it's at a healthy level, start the second cycle.