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Tablets can vary in many ways including size, shape, color, Disintegration/______, and usage.
Dissolution
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Advantages of oral tablets are
- cheap
- easy to package/transport
- Stability
- tamper resistent
- patient acceptance
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Disadvantages of oral tablets
- limited dosage flexibility
- complex formulation requiremtns
- esophogeal adheasion
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T/F some machines can produce 250 tablets for second
True
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T/F powder is fed into Dials and compressed at high pressure using kickers.
False, Fed into dies and compressed with punches.
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Paradox for compressed tablets, to make it strong enough for processing and handling but capable of _______
Breaking down upon administration
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Essential properties of powders are _____ and _______.
- Fluidity- powder must flow into dies well
- Compresability- must form stable intact mass when pressure is applied
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These are used to improve fluidity
Glidants, lubricants and granulation
-
these are used to improve compressability
special excipients and granulation
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Purposes of granulation are to prevent _______, improve powder fluidity, and improve powder _____.
- Stratification
- Compressability
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Excipients for Tablet formulation are _______ (diluents), _______, ______, _______, and _____.
- Filler- starch
- adhesive- Providone
- glidant- colloidal silica, talc
- Lubricant- magnesium stearate
- disintegrant- starch, cellulose derivatives
-
Tablet formulation approaches
Wet/dry granulation and direct compression.
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Direct compression is used for drugs with both ____ and _____ properties.
Cohesive and flow, not many drugs have both properties.
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Tablet coating reasoning
- Protect ingredients
- mask taste
- facilitate swallowing
- mask differences
- tablet ID
- manufacture distribution
- Enteric and controlled release
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Types of coating are
- Sugar coating without indentations
- Film coating wtih indentations
-
Pioneers of gel coating are
Geltab
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The special pH polymer used in enteric coating is
cellulose acetate pthalate
-
Enteric polymers work by _____ groups on polymer backbone which allows solubility to increase at a pH of ____.
-
Tests to assure tablet quality are
Appearance- mottling or cracking
Thickness- determine by fill volume, die diameter, comp pressure.
- Hardness- crushing strength required
- Friability- tendency to crumble
- USP tests- drug content and drug release
-
Tests for drug content
Weight variation- asseses drug content uniformity
Drug content uniformity- uniform active ingredient
-
Tests for drug release
Disintegration test- complete disintegration (no palpable core), and basket rack assembly.
*** Note fluids and disintegration times can vary according to drug monograph.
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Sublingual NTGs must disintegrate in under _ minutes.
2 minutes
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