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FLUOXETINE
SSRI (PROZAC)
LONG 1/2 LIFE (NORFLUOXETINE METABOLITE SO GREAT FOR NONCOMPLIANCE)
INHIBITS 2D6, 3A3/3A4
ACTIVATING - SO TAKE IN MORNING
HA, STOMACH UPSET, WEIGHT LOSS, SEXUAL DYSFUNCTION
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SERTRALINE
SSRI (ZOLOFT)
50-200MG/DAY
INHIBITS 2Cs, 2D6
ACTIVATING
INTERMEDIATE 1/2 LIFE, SO COULD LEAVE WITHDRAWAL SYMPTOMS (FLU LIKE)
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PAROXETINE
SSRI (PAXIL)
20-60MG/DAY
*LEAST ACTIVATING + ANTICHOLINERGIC SO NOT FOR WEARY/MOTOR RETARDED
POTENT 2D6 INHIBITOR
INTERMEDIATE 1/2 LIFE SO WITHDRAWAL SYMPTOMS
INCREASE IN CONGENITAL MALFORMATIONS, PREGNANT WOMEN STAY AWAY (ACCORDING TO ONE STUDY AT LEAST)
POSSIBLE TERATOGEN
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CITALOPRAM
SSRI (CELEXA) R & S ISOMERS
20-60MG/DAY
- 3A4 INHIBITOR
- 2D6 INHIBITOR (WEAK)
- POSSIBLY LESS SEXUAL DYSFUNCTION
- WITHDRAWAL SYMPTOMS
- HIGHLY SERT SELECTIVE
- ACTIVATING
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FLUVOXAMINE
SSRI (FOR OCD, NOT MDD) (LUVOX)
50-300MG/DAY
- INDICATED FOR OCD
- LONG 1/2 LIFE
INHIBITS 1A2, 3A4, 2C19
- WITHDRAWAL SYNDROME
- N&V STOMACH ISSUES, AGITATION, INSOMNIA, SEXUAL DYSFUNCTION
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VENLAFAXINE/DESVENLAFAXINE
SNRI (EFFEXOR/PRISTIQ)
- 37.5-225MG/DAY
- SHORT 1/2 LIFE SO BID
- LOWEST PROTEIN BINDING
MINOR 2D6 INHIBITOR, FEW DRUG INTERACTIONS
DOSE RELATED HTN DUE TO NE COMPONENT, SO MORE DANGEROUS IN OVERDOSE CASES
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DULOXETINE
- SNRI (CYMBALTA)
- ALSO FOR DIABETIC NEUROPATHY/PAIN
- 30-90+MG/DAY
- TMAX 6HRS, 1/2 LIFE 15HRS
- METABOLIZED BY 1A2 AND 2D6, SO INHIBITORS OF THESE WILL INCREASE CYMBALTA CONCENTRATIONS
- INHIBITS 2D6 MODERATELY
NAUSEA, DRY MOUTH, CONSTIPATION, INSOMNIA, DIZZINESS
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BUPROPION
DAT/NET BLOCKER (WELLBUTRIN/ZYBAN)
- CONTROLLED RELEASE UP TO 200MG BID
- EXTENDED RELEASE QD <450MG/DAY
*LOWERS SEIZURE THRESHOLD
*LESS SEXUAL DYSFUNCTION THAN SSRIs, AND NO WITHDRAWAL
AGITATION, NAUSEA, INSOMNIA, PSYCHOSIS, DOSE RELATED SEIZURES
DRUG INTERACTIONS WITH ANTIEPILEPTICS, AND RITONAVER WOULD INCREASE LEVELS OF BUPROPION
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TRAZADONE/NEFAZADONE
- (DESYREL)
- MORE FOR SLEEP AT 50MG THAN ANTIDEPRESSANT
3A4 INHIBITOR, SO BAD WITH RITONIVIR AND BENZOS
COMBINE WITH SSRIs AND MAOIs FOR SEROTONIN SYNDROME
PRIAPISM
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MIRTAZEPINE
REMERON
ANTIHISTAMINIC AND SEDATIVE AT LOW DOSES, NOT SO MUCH AT HIGHER DOSES
- WEIGHT GAIN
- LIVER ENZYME ELAVATION (MONITOR LFTs)
METABOLIZED BY 3A4, 2D6, 1A2, 2C9, SO VERY FEW DRUG INTERACTIONS
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