-
Introns
are only found in eukaryotic genes.
-
The central dogma of biology
DNA -> RNA -> protein
-
HDAC
- stands for histone deacetylase and is responsible
- for the deacetylation of histones.
-
HAT
- Histone acetyltransferase and is responsible for
- acetylating histones.
-
Regulation of chromatin structure
- is achieved through regulating the enzymatic activity
- of HDAC and HAT.
-
Transcription Factors
- control gene expression by regulating or inhibiting
- gene transcription.
-
RNA processing
- consist of capping, splicing, polyadenylation, and
- RNA editing.
-
What are the four elements found within an intron?
- a 5', 3' splice site, branch point, and a
- polypyrimidine tract.
-
Can splicing be regulated?
Yes
-
How is splicing regulated?
- Through the activity of SR proteins and hnRNP
- proteins.
-
(True or False) Alternative splicing is a way to
increase protein diversity.
True
-
(True or False) When iron levels are low, ferritin
mRNA is less stable.
True
-
(True or False) When iron levels are high, Ferritin
mRNA has a longer half-life.
True
-
(True or False) When iron levels are low, TfR
(transferrin receptor) mRNA has a short-half life.
False
-
(True or False) When iron levels are high, TfR
mRNA is less stable.
True
-
(True or False) Nonsense mediated decay is a
pathway for regulating RNA degradation.
True
-
Prader-Willi Syndrome
- results from a paternal deletion of chromosome 15
- q11-q13.
-
Angleman syndrome
- results from a maternal deletion of chromosome 15
- q11-q13.
-
DNA methylation commonly occurs in:
GC rich regions of the promoter.
-
(True or False) DNA methylation is method of
turning off gene expression.
True.
-
A prokaryotic operon consist of:
a promoter and structural genes.
-
(True or False) Transcription and Translation in
Prokaryotic organisms are coupled?
True
-
(True or False) In prokaryotes, a repressor is
responsible for inhibiting gene expression.
True
-
HDAC will inactivate or activate gene expression.
Inactivate
-
HAT will inactivate or activate gene expression.
Activate
-
What is the amino acid that is specifically acetylated
by HAT.
Lysine
-
The conversion of C to U in Apoprotein produces:
Apo B48
-
A message that is not properly spliced will most
likely be:
degraded by the NMD pathway.
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