Physio- endocrinology

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Type I DM is +/- of:

insulin
Type II is +/- of

Relatively - insulin, Insulin Resistance
Clinical Signs of DM (7)
- PU/PD
- polyphagia
- Anorexia/vomiting (later)
- Weight loss
- Swelling
- Neuropathies/Microangiopathies
- UTI
<Metabolic/Physiological changes that result from DM (5):
- Hyperglycemia (decreased cell uptake and increased gluconeogenesis)
- Proteolysis
- Lipolysis
- Reduced glycogenesis
- Reduced protein synthesis
Clinical Signs of hyperthyroidism (8):
- Weight loss/muscle atrophy
- Appetite: Normal-Increased
- Nervousness
- Heat Intolerance
- Tachycardia/hypertension
- Diarrhea
- PU/PD
- Skin Changes
Clinical signs of Hypothyroidism (9):
- Lethargy
- Weight Gain
- Exercise Intolerance
- Heat Seeking
- Myxedema
- Dry skin
- Alopcia
- Hyperpigmentation
- Dec Reproduction
Goiter results from a ____ deficiency

I
Goiter Clinical signs are similiar to:

Hypothyroidism
Growth hormone stimulates which metabolic pathways?
- Lipolysis
- Insulin Resistance
- Protein Synthesis
Growth Hormone deficiency in juvenile => (2)
- Dwarfism
- Alopecia
Growth Hormone deficiency in Adult => (2)
- Aging
- Panhypopituitarism (FSH/LH, ACTH, Thyroid)
Growth Hormone Excess in juveniles =>

Gigantism
Growth Hormone Excess in adults =>
- Acrmegaly
- Increased bone/cart in face/joints
- Cardiac Hypertrophy
- Seconday DM
_____ -> Excess GH in Dogs
_____ -> Excess GH in Cats
- ++ progesterone -> Dogs
- Pituitary tumor -> Cats
Decreased Glucocorticoids
- Addison's
- (Also Decreased Mineralcorticoids)
Increased Glucocorticoids =>

Cushings
Stress Hormones =

Glucocorticoids
Primary metabolic functions of glucocorticoids
- Increase Gluconeogenesis
- Increase Glycogenesis
- Increa
Primary metabolic functions of glucocorticoids (3)
- Increase Gluconeogenesis
- Increase Glycogenesis
- Increase Proteolysis
Organs/Tissues affected by Glucocorticoids:
- Liver
- GI
- BG
- CNS/Pituitary
- Muscle
- CT
- Fat
- Bone
- Blood
- Inflammatory Mediators
POMC => (4)
- a-MSH
- B- Endorphin
- CLIP
- ACTH
Primary Causes of Cushings:
- Adenoma of Ant. Pituitary (most common)
- Iatrogenic
- Pars Intermedia Tumore (Horses
- Adenoma of Adrenal Gland (rare)
Clinical Signs of Cushing's (13):
- Muscle Atrophy
- Weakness
- Think Skin
- BILATERAL hair loss
- Slow shedding (horses)
- Lightened coat color
- Potbelly
- PU/PD
- Suppressed Immune
- Polyphagia
- Panhypopituitarism
- Behavoir Changes (horse)
- Hyperpigmentation
Mitotane Tx is used to:

supress adrenocortex
Renal Hypertension is caused by

Hyperaldosteronism
Mineralcorticoid Deficiency =>

Na and Water Retention

Author

Anonymous

47922

Card Set

Physio- endocrinology

Description

physio

Updated

2010-11-07T19:11:55Z

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