-
-
5-FU
- Hand-foot syndrome
- Diarrhea
- Mucositis
- Bolus- immunosuppressive
- Infusion- Hand-Foot
-
Capecitabine
- Hand-Foot
- mucositis
- diarrhea
- Less immunosuppresive
-
Oxaliplatin
- Peripheral neuropathy
- Least: immunosuppresive, renal toxicity, and emetogenic
-
Irinotecan
- myelosuppression: dose-limiting
- diarrhea: dose-limiting
- alopecia
- rash, fever, malaise, mucositis
-
Bevacizumab
- Blackbox Warning: GI perforation, wound healing, hemorrhage
- Rare proteinuria, CHF
- Epistaxis
- Infusion reactions, diarrhea
-
Cetuximab
- acneiform rash
- diarrhea
- rare infusion reaction
-
Pantumumab
- skin rash
- hypomagnesiemia
- paronychia
- fatigue
- abdominal pain
- nausea
- diarrhea
- Blackbox Warning: Derm. & Infusion reaction
-
-
Carboplatin
- Less N/V- required 5HT3
- less renal dysfunction
- myelosuppression
-
Cisplatin
- more renal toxicity
- less myelosupressive
- Most emetogenic
-
Docetaxel & Paclitaxel
- Edema
- Alopecia
- Mucositis
- Neutropenia/febrile neutropenia
- Peripheral neuropathy
- arthralgia/myalgia
- hypersensitivity
- skin/nail toxicity
- fatigue
- mouth sores
-
Vinca alkaloids
- Alopecia
- N/V
- Peripheral neuropathy
- Constipation
- Diarrhea
-
Vincristine
- Neurotoxicity
- Constipation
- Orthostatic hypotension
-
Vinblastine, Vinorelbine
- myelosuppression
- rare muscle aches w. vinblastine
-
Irinotecan
- diarrhea- acute and delayed
- alopecia
- N/V
- myelosuppression
- hepatic dysfunction
-
Etoposide
- myelosuppression
- alopecia
- N/V/D: worse with PO
- asthenia/malaise
- secondary leukemias, SJS, toxic epidermal necrolysis
- orthostatic hypotension
-
Premetrexed
- rash
- myelosuppression, fever/infection, stomatitis/pharyngitis
-
Erlotinib
- diarrhea
- acneiform
- rash- correlate with response
-
-
Hormonal Therapy- Class Effects
- Hot flashes
- decreased libido
- imptence
- increased abdominal fat
- gynecomastia
- emotional lability
- weight gain
- fluid retention
- unfavorable lipid profile changes
-
Dearelix
- injection site reaction, hormonal effects
- increases AST/ALT
-
Anti-Androgens: Bicalutamide, Flutamide, Nilutamide
- soft stools
- hormonal effects
-
Nilutamide- also
- N/V
- disulfram-like reaction
- hypertension
-
Ketoconazole
GI upset- take with food
-
Cabazitaxel
- neutropenia
- febrile neutropenia
- diarrhea
- hematologic toxicities
-
Estramustine
- edema
- gynocomastia
- leukopenia
- THROMBOEMBOLISM
-
Mitoxantrone
- CARDIOTOXIC
- myelosuppression
- mild N/V
- mucositis
- alopecia
-
-
Goserlin & Leuprolide
- Hot flashes
- Bone loss*
- injection site reaction
-
Fulvestrant
- Hot flashes*
- injection site pain
-
Tamoxifen & AI's
- Hot flashes*
- vaginal symptoms*
- fatigue
- weight gain
- reduced libido
- thromboembolism
-
Tamoxifen only
- endometrial cancer
- cataracts
-
AI's only
- bone loss/osteoporosis
- arthralgias/myalgias
- CVD/cardio risks (small)
-
Docetaxel
- MORE
- myelosuppression, edema, skin/nail toxicities
-
Paclitaxel
- MORE
- hypersensitivity reactions
- arthralgia/myalgia
- neuropathy
-
Doxorubicin
- Cardiotoxicity (CHF)
- myelosuppression
- N/V
- alopecia
- mouth sores
- red urine/tears
- vesicant
- leukemia
-
Cyclophosphamide
- myelosuppression
- nausea
- alopecia
- sterility/amenorrhea
- hemorrahagic cystitis- rare
-
Epothilone
- myelosuppression
- neuropathy
- hypersensitivity reactions
- diarrhea
- myalagias
- alopecia
-
trastuzumab
- allergic infusion reactions- fever/chills
- rare- cardiotoxicity (CHF)
-
Lapatinib
- diarrhea/ GI upset
- acne-like rash
- hand and foot syndrome/inflamation
- rare: cardiotoxicity, myelosuppression
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