what are the three systems for ATP production in working muscle?
immediate sources- ATP, creatine phosphate, adenylate kinase
anaerobic metabolism- glycogen-lactate system
aerobic (oxidative) metabolism- glucose, fatty acids, amino acids
what is the function of ANT?
transporter of ADP and ATP, it is an antiport transpoter, 1 ATP in for 1 ADP out, resides on inner mitochondrial membrane
what is the Pasteur Effect?
increased rate of glucose metabolism seen under anaerobic conditions
what is the major strategy of AMPK in in abrubt exercising muscle?
inhibit ATP consumption (anabolic pathways)
stimulate ATP production (catabolic pathways)
what are two of the roles of calcium in the muscle when exercise has started (abrupt)?
initiates muscle contraction
binds to and activates calmodulin (the subunit of glycogen phosphorylase kinase-helps in activation of glycogen phosphorylase and breakdown of glycogen)
how many ATP are produces form glycolysis via blood glucose?
glycolysis via glycogen?
what is the rate limiting enzyme/step in glycolysis?
what is the role of FAT (fatty acid transporter)?
transports fatty acids across the sarcolemma of muscle cell
what is the role of FABP (fatty acid binding protein)?
carries fatty acids to mitochondria where they are activated to fatty acyl CoA
Biochemistry of Skeletal Muscle and Heart