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Pentose phosphate pathway alternate names
- Hexose monophosphate Shunt
- 6-phosphoglucuronate pathway
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Products of the PPP are:
- NADPH (reductive biosynthesis)- fatty acids/steroids
- Ribose-5-phosphate for nucleic acids
- Glycolytic intermediates- glyceraldehyde-3-phosphate
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Glycolysis, Pyruvate dehydrogenase, and the Tricarboxylic acid cycle are inhibited by ______ and stimulated by ___.
- inhibited by NADH, ATP
- stimulated by NAD+
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Higher requirement for ribose-5-phosphate than NADPH G6P is converted to _________ and ___________.
fructose-6-phosphate and glyceraldehyde-3-phosphate by glycolytic path.
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T/F PPP stage 1 is reversible
False, irreversible... decarboxylation of hexose to pentose yielding NADPH is irreversible.
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Stage II in PPP is _____
Reversible, it leads to glycolytic intermediates.
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Oxidative reactions (stage 1) are _____ whereas nonoxidative reactions (stage 2) are ______.
Irreversible, reversible
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G6P important features (3)
- Catalyzes firststep in PPP
- RLS
- uses NADP as cofactor (makes NADPH)
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NADPH and NADH differences
NADPH uses high energy electrons for biosynthesis, NADH uses them to make energy (ATP)
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Glutathione functions
major cellular reductant and sulfhydryl buffer, makes drugs more soluble.
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Cytochrome P450 requires ______ as a cofactor to detoxify drugs, steroids, and alcohols.
NADPH
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G6P dehydrogenase mutations
- Slightly decrease life span
- alter function of G6PD
- alter Km and Vmax
- resist flaciparum malaria
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Drugs that exacerbate G6PD
Antiobiotics, antimalarials, Antipyretics (acetanilide)
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Glucoronic acis is conjugated to ______ and ________ compounds and produce a strongly acidic compound which is more water soluble.
exogenously and endogenously.
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UDP-glucose dehydrogenase is used in what synthesis?
Glucoronic acid synthesis.
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