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-stasis
controlling, stopping
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homeostasis
steady state or continual blancing act of the body system
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pathogen
disease producing agent
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immune system
defending the body against disease via immune respose
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blood, immune and lymph
body's defense mechanisms
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hematologist
one who studies blood
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immun/o
safety, protection
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immunology
the study, diagnosis, and treatment of diseases that affect the body's mechanisms
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hematology
the study, diagnosis, and treatment of diseases of the blood and blood-forming organs
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immunologist
specialist in the fieldo f immunology
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hematic and lymphatic
flow through separate yet interconnected channels. Both contain vessles and liquids
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immune system
complex set of levels of protection for the body; includes blood and lymph cells
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hematopoiesis
the process of blood formation.
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stem cell
cell from which all blood cells originate
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cells and plasma make up:
blood
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erythrocyte
red blood cell RBC
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leukocyte
white blood cell WBC
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thrombocyte
clotting cells, cell fragments, or platelets
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-globin
protein substance
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hemoglobin
protein-iron pigment in RBC
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-poietin
forming substance
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erythropoietin
hormone from the kidneys that stimulates bone marrow formation
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hemosiderin
decomposed RBC into an iron pigment
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hemolysis
break down of RBCs
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morphology
the study of shape or form (detection of abnormal RBCs)
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granulocyte
polymorphonucleocyte; PMNs or polys; have small grains within the cytoplasm and multilobed nuclei
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eosinophil
(eosinios); cells that absorb an acidic dye and turn red. Positive response for defense against allergens and parasites.
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neutrophils
- do no absorb acidic or basic dyes, thus purple
- a.k.a. phagocytes, thus combat bacteria in pyogenic "invasions"
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phagocyte
consume the enemy and remove the debris
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basophil
cells that absorb a basic dye; stain bluish. combat parasites. release histamine and heparin; heal damaged tissue
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anticoagulant
exp. heparin
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agranulocyte
lack of granules; a.k.a. mononuclear leukocyes = have one nucleus
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monocyte
cells named for single large nucleus
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macrophages
matured monocytes; eat pathogens & effective against severe infections
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lymphocyte
(lymphs); immune response involving antigens(foreign) and antibodies(neutralizers)
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thrombocyte
platelets, round or oval shape, aide in coagulation.
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coagulation
process of changing a liquid to a solid
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agglutinate
clump together; release X factor, react w/ prothrombin, form thrombin, converts to fibrinogen, then to fibrin and lastly a meshlike clot = hemostasis
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-thrombin
clotting substance
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prothrombin
reacts w/ factor X in the presence of calcium to from thrombin
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fibrinogen
conversion step from thrombin to fibrin in the agglutination process
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-stasis
stopping, controlling
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hemostasis
control of blood flow, stopping the bleeding
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plasm/o
Plasma: liquid portion of blood composed of: H2O, inorganic and organic substances, waste, plasma proteins
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ser/o
serum: plasma minus clotting (plasma) proteins
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Serum =
Plasma - (Prothrombin + Fibrinogen)
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antigens
substances that produce an immune response
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agglutinogen
antigens found in blood that cause blood to clump
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antibodies
substances produced by the body that nullify or neutralize antigens
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agglutinin
when antigen is agglutinogen, antibody is agglutinin; substance that clumps
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universal recipient
person w/ type AB blood (can receive any)
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universal donor
can give any, has neither A nor B antigens, thus no clumping
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Rh factor
another antigen
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-lytic
pertaining to breaking down
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hemolytic
pertaining to the breaking down of blood
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Hemolytic disease of the newborn (HDN)
Rh- mom has Rh+ antibodies to fetus, if another Rh+ pregnancy, antibodies will destroy fetal blood.
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lymph/o
lymph or interstitial fluid
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macrophage
monocytes become macrophages, destroy pathogens, and collect debris from damaged cells.
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append/o, appendic/o
appendix
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Lymphatic organs
spleen, thymus gland, tonsils, and appendix, Pyer's patch
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cytokine
chemical messangers that direct immune cellular interactions
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lymphokine
secreted by lymphocytes (B cells or T cells)
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monokine
secreted by monocytes and macrophages
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interleukin
cytokin that sends messages among leukocytes
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nonspecific immunity
ways the body protects itself with out "recognizing" pathogen
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specific immunity
natural or aquired
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mechanical immunity (1st line in non specific)
skin, mucous membrane
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physical immunity (1st line in non specific)
coughing, sneezing, vomiting, diarrhea
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chemical immunity (1st line of non specific)
tears, saliva, perspiration
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Phagocytosis (second line of non specific)
pathogens consumed by neutrophils and monocytes
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inflammation (second line of non specific)
immediate vasoconstriction and vascular permeablilty
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infection
inflammation caused by pathogen
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pyrexia (second line of non specific)
fever functioning to increase the action of phagocytes and decreasing the viability of certain pathogens.
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protective proteins
second line of defense non specific
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interferons
interfere with viral replication
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complement proteins
become activated in the presence of bacteria, enabling them to lyse the organisms
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natural killer (NK) cells
lymphocyte acts to kill cells that have been infected by pathoges
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genetic
inherited ability (to resist certain diseases_
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acquired
bodys ability to respond (natural and artificial)
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immunoglobulins (Ig)
antibodies; part of specific immunity
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cell-mediated immunity T cells
attack atigens directly
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humoral
pertaining to liquid or secretion of antibodies
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Humoral immunity B cells
antibody-mediated immunity
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Active acquired immunity
natural: memory cells
artificial: vaccination (immunization)
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passive acquired immunity
Natural: passage of antibodies through the placenta
Artificial: immunoglobulins harvested from a donor who developed resistance against specific antigens.
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append/o, appendic/o
appendix
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lymphaden/o
lymph gland (node)
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immun/o
safety, protection
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-globin
protein substance
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-lytic
pertaining to breaking down
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-poietin
forming substance
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-stasis
controlling, stopping
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-thrombin
clotting substance
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dyscrasia
disease, more specifically to do w/ blood or bone marrow
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Anemia
a decrease in red blood cells, hemoglobin, and/or hematocrit
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-rrhagic
pertaining to bursting forth
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acute posthemorrhagic anemia
RBC deficiency caused by blood loss
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B12 deficiency
- insufficient levels of cobalamin (aka B12), essential for RBC maturation.
- Due to inadequate diet or absence of intrinsic factor.
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Chronic blood loss
long-term internal bleeding. May cause anemia
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folate deficiency
anemia as a result of a lack of folate from dietary, drug-induced, congenital, or other causes.
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hypovolemia
deficient volume of circulating blood
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sideropenia
condition of having reduced numbers of RBCs b/c of chronic blood loss, inadequate iron intake, or unspecified causes. A type of iron deficiency anemia.
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pernicious anemia
progressive anemia that results from a lack of intrinsic factors essiential for the absorption of vitamin B12.
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aplastic anemia
suppression of bone marrow function leading to a reduction in RBC production. Although causes of this often fatal type of anemia may be hepatitis, radiation, or cytotoxic agents, most causes are idiopathic. Also called hypoplastic anemia.
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-lytic
pertaining to destruction
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hemolytic anemia
a group of anemias caused by destruction of red blood cells
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immune
safety, protection
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-lytic
pertaining to destruction
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autoimmune acquired hemolytic anemia
anemia aquired by the body's destruction of its own RBCs by serum antibodies
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-lytic
pertaining to destruction
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nonautoimmune aquired hemolytic anemia
anemia that may be drug induced or may be caused by an infectious disease
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sickle cell anemia
inherited anemia characterized by crescent-shaped RBCs which block capillaries and decrease O2 supply to cells. Sickle cell crisis is acute, painful exacerbation of sickle-cell anemia.
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thalassemias
group of inherited disorders of people of Mediterranean, African, and Southeast Asian descent, in which the anemia is the result of a decrease in the synthesis of hemoglobin, resulting in decreased production and increased destruction of RBCs
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pancytopenia
deficiency of all blood cells caused by dysfunctional stem cells
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-philia
attraction condition
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hemophilia
group of inherited bleeding disorders characterized by a deficiency of one of the factors necessary for the coagulation of blood
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polycythemia vera
chronic increase in the number of RBCs and the concentration of hemoglobin. "Vera" signifies that theis is not a sequela of another condition.
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purpura
bleeding disorder characterized by hemorrhage into the tissues
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thrombocytopenia
deficiency of platelets that causes an inability of the blood to clot. The most common cause of bleeding disorders.
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-cytosis
abnormal increase in cells
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leukocytosis
abnormal increase in WBCs. Abnormal increases in each type of granulocyte are termed eosinophilia, basophilia, or neutrophilia, where the suffix -philia denotes a slight increase. Abnormal increase in the number of each type of agranulocyte are termed lyphocytosis or moncytosis.
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leukopenia
abnormal decrease WBCs. Specific deficiencies are termed neutropenia, eosinopenia, monocytopenia, and lymphocytopenia. Also called leukocytopenia.
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neutropenia
abnormal decrease in neutrophils due to disease process. Formerly called agranulocytosis
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edema
abnormal accumulation of fluid in the intersitial spaces of tissues.
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hypersplenism
increased function of the spleen, resulting in hemolysis.
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lymphadenitis
inflammaation of a lymph node.
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lymphadenopathy
disease of the lymph nodes or vessles that may be localized or generalized
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lymphangitis
inflammation of lymph vessels
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lymphedema
accumulation of lymphatic fluid and resultant swelling caused by obstruction, removal, or hypoplasia of lymph vessels.
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lymphocytopenia
deficiency of lymphocytes caused by infectious mononucleosis, malignancy, nutritional deficiency, or a hematologic disorder.
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lymphocytosis
abnormal increase in lymphocytes
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mononucleosis
increase in the number of mononuclear cells (monocytes and lympocytes) in the blood caused by the epstein-Barr virus (EBV). Can result in splenomegaly (enlarged spleen).
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acquired immunodeficiency syndrome (AIDS)
caused by HIV and transmitted through body fluids. HIV attacts helper T cells which diminishes the immune response
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allergy
immune system's overreaction to irritants that are perceived as antigens. The substance that causes the irritation is called an allergen. Also called hypersensitivity.
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anaphylaxis
extreme form of allergic response in which the patient suffers severely decreased blood pressure and constriction of the airways.
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delayed allergy
immune system hypersensitivity caused by activated T cells that respond to an exposure of the skin to a chemical irritant up to 2 days later. An example would be poison ivy. The resulting rash is called contact dermatitis.
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immediate allergy
Hypersensitivity of the immune system caused by IgE. Example are tree and grass pollens.
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immun/o
safety, protection
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autoimmune disease
T cells attack own cells, causing tissue damage and organ dysfunction. Myasthenia gravis, rheumatiod arthritis, systemic lupus erythematosus, and multiple sclerosis are exapmple of autoimmune diseases.
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thymoma
noncancerous tumor of epithelial origin that is often associated with myasthenia gravis
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acute lymphocytic leukemia (ALL)
a.k.a. acute lymphoblastic leukemia, characterized by the uncontrolled proliferation of immature lymphocytes. Itis the most common type ofleukemia for individuals under age 19.
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-genous
pertaining to originating from
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acute myelogenous leukemia (AML)
rapidly progressive form of leukemia develops from immature bone marrow stem cells.
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chronic lymphocytic leukemia (CLL)
slowly progressing form of leukemia in which immature lymphocytes proliferate. Occurs most frequently in middle age adults, rarely in children.
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chronic myelogenous leukemia (CML)
immature bone marrow cells proliferate, similar to CLL
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Hodgkin lymphoma
cancer diagnosed by detection of a type of cell specific only to this diserder: Reed-Sternberg cells.
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myeloma, multiple
a.k.a. plasma cell dyscrasia or myelomatosis, this rare malignancy of plasma cells is formed from B lymphocytes. It is called "multiple" myeloma because the tumors are found in many bones. If it occurs in only one bone, the tumor is referred to as a plasmacytoma.
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non-Hodgkin lymphoma
a collection of all other lymphatic cancers but Hodgkin lymphomas. This type is the more numerous of the two lymphomas and is the sixth most common type of cancer in the US
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thymoma, malignant
a.k.a. thymic carcinoma is a rare malignancy of the thymus gland particularly invasive and unlike its benign form, is not associated with autoimmune disorders.
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lymphadenography
radiographic visualization of the lymph gland after injection of a radiopaque substance. Also called lymphography.
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lymphangiography
radiographic visualization of a part of the lymphatic system after inejction with a radiopaque substance.
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splenic arteriography
radiographic visualization of the spleen with the use of a contrast medium.
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AIDS tests- ELISA, Western blot
tests to detect the presence of HIV types 1 and 2.
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allergy testing
series of tests involving a patch, scratch, or intradermal injection of an attenuated amount of an allergen to test for hypersensitivity.
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basic metabolic panel (BMP)
group of blood tests to measure calcuim, glucose, electrolytes such as sodium (Na), potassium (K), and chloride (Cl), creatinie, and blood urea nitrogen (BUN).
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blood cultures
blood samples are submitted to propagate microorganisms that may be present. Cultures may be indicated for bacteremia or septicemia, or to discover other pathogens (fungi, viruses, or parasites)
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complete blood count
twelve tests, including RBC (red blood cell count), WBC (white blood cell count), Hb (hemoglobin), Hct/PCV (hematocrit/packed-cell volume), and diff (WBC differential).
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comprehensive metabolic panel (CMP)
set of 14 blood tests that add protein and liver function tests to the BMP. Glucose is also measured with a different method than in the basic panel.
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Coombs antiglobulin test
blood test to diagonose hemolytic disease of the newborn (HDN), acquired hemolytic anemia, or a transfusion reaction.
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diff count
meausure of the numbers of the different types of WBCs
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erythrocyte sedimentation rate (ESR)
measurement of the time mature RBCs to settle out of a blood sample after an anticoagulant is added. An increased ESR indicates inflammation.
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heatocrit (Hct), packed-cell volume (PCV)
measure of the percentages of RBCs in the blood.
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hemoglobin (Hgb, Hb)
iron-containing pigment of RBCs that carries oxygen to tissues
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mean corpuscular hemoglobin (MCH)
test to measure the average weight of hemoglobin per RBC. Useful in diagnosing anemia
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mean corpuscular hemoglobin concentrate (MCHC)
test to measure the concentration of hemoglobin in RBCs. This test is useful for measuring a patient's response to treatment for anemia.
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monospot
test for infectious mononucleosis.
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partial thromboplastin time (PTT)
test of blood plasma to detect coagulation defects of the intrinsic system; used to detect hemophilias.
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prothrombin time (PT)
test that measures the amount of tie taken for clot formation. It is used to determine the cause of unexplained bleeding, to assess levels of anticoagulation in patients taing warfarin or with vitamin K deficiency, and to assess the ability of the liver to syntheisze blood-clotting proteins.
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Schillings test
nuclear medicine test used to diagnose pernicious anemia and other metabolic disorders
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apheresis
temporary removal of blood from a donor, in which one or more components are removed, and te rest of the blood is reinfused into the donor. Esamples include leukapheresis, removal of WBCs; plasmapheresis, removal of plasma; and plateletpheresis, rmoval of thrombocytes. Also called pheresis.
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bone marrow transplant (BMT)
the transplantation of bone marrow to stimulate production of normal blood cells.
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autologous bone marrow transplant
Harvesting of patient's own healthy bone marrow efore treatment for reintroduction later.
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homologous bone marrow transplant
transplantation of healthy bone marrow from a doner to a recipient to stimulate formation of new blood cells
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blood transfusion
intravenous transfer of blood from a donor to a recipient, giving either whole blood or its components.
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autologous transfusion
process in which the donor's own blood is removed and stored in anticipation of a future need
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autotransfusion
process in which the donor is transfused with his/her own blood, after anticoagulation and filtration, from an active bleeding site in cases of major surgery or trauma.
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adenoidectomy
removal of the adenoids. Also called the pharyngeal tonsils.
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biopsy (bx) of lymphatic structures
removal of the lymph nodes or lymphoid tissue as a means to diagnosis and treatment
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lymphadenectomy
removal of a lymph node.
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splenectomy
removal of the spleen
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anticoagulants
drugs that prevent the coagulation of blood and the formation of thrombi.
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antiplatelets
drugs that inhibit the function of platelets or destroy them.
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blood-flow modifiers
drugs that promote blood flow by keeping platelets from clumping or decreasing blood viscosity.
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colony-stimulating factors (CSFs)
agents tat stimulate the production of white blood cells in the bone marrow
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erythropoietic agents
growth factors that increase production of RBCs by stimulating erythropoiesis.
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hematinics
drugs that increase the number of erythrocytes and or hemoglobin concentration in the erythrocytes usually to treat iron-deficient anemia.
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hematopoietic agents
drugs that stimulate blood cell production. Subdivisions of this class include colony-stimulating factors, erythropoietic agents, and thrombopoietic factors.
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hemostatics
drugs that help stop the flow of blood.
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thrombopoietic factors
agents that stimulate the production of thrombocytes or platelets
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antihistamines
drugs that block histamine (H1) receptors to manage allergy symptoms.
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anti-IgE agents
monoclonal antibodies that treat allergic asthma and allergic rhinitis.
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antineoplastics
drugs used to treat cancer by preventing growth or promoting destruction of neoplastic (tumor) cells.
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antiretrovirals
drugs that manage the replication of HIV and its progression into AIDS.
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crticosteroids
drugs also known as steroids that suppress the immune system and reduce inflammation
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cytotoxic agents
drugs used as immunosuppressants or antineoplastics in order to damage or destroy cells.
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immunosuppressants
drugs that reduce the immune response.
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leukotriene recepor antagonists
drugs tat block leukotrienes to manage later stages of allergic reactions; espically used to manage allergic asthma.
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protease inhibitors
these drugs are a type of antiretroviral and are used to treat HIV infection. By blocking the production of an essential enzyme called protease, these drugs keep the virus from replicating.
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Vaccines (immunizations)
substances administered to induce immunity or reduce the pathologic effects of a disease. Examples are the measles, mumps, rubella vaccine and the chicken pox vaccine.
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