Path Block 3 (GIb)

  1. Where do most (95%) of hte Malignancues of the Stomach originate?
    • originate in the surface glandular epithelial
    • cells of the stomach (adenocarcinoma)

  2. What Classification do we used for Adenocarcinomas of the stomach?
    • The Lauren Classification
    • - Intesstinal
    • - Diffuse
  3. What do you see in the Intestinal Type of Cancer?
    • -non-Signet ring
    • - associated with H. Pylori
    • -Declining in incidence
    • -Occurs predominately in gastric antrum/pylorus; lesser > greater curvature
  4. What do you see in the Diffuse type of Stomach cancer?
    • •Increasing incidence
    • -Signet rings
    • No association with H.pylori
    • •Dismal 5-year survival, none to 1 or 2%
    • Occur throughout the stomach
    • •Linits Plastica!
  5. how is gastric carcinoma classified?

    What is Linitis Plastica?
    By depth of invasion

    • Linitis plastica is an extreme form of flat or depressed advanced gastric carcinoma.Linitis plastica
    • means thickening of the stomach
  6. Image Upload 2
    This is Gastric Carcinoma

    See Heeped up Borders
  7. Image Upload 4Image Upload 6
    • Both are Gastric cancer.
    • 1st-- See signet ring cells= Diffuse type
    • 2nd-- see no signet rings just gland formation = Intestinal type
  8. Image Upload 8
    • This is Gastric Cancer (Linitis Plastica type)
    • It is a diffuse type= Signet rings and NOT H.Pylori associated.
  9. Name some other Gastric Tumors (LLMMN)
    • •Lymphoma (MALT, B-cell)
    • •Mesenchymal (GIST)
    • •Neuroendocrine (Carcinoid)
    • •Lipoma
    • •Metastatic
  10. Image Upload 10
    This is a Gastric MALT (B cell) Lymphoma

    It may be H. Pylori associated
  11. What does GIST stand for?
    Where does it arise from?
    What # occur in the stomach?
    Any markers?
    What do you see histologically?
    Are they aggressive?
    Treat with?
    • Gastrointestinal Stromal Tumor
    • Intestinal cells of Cajal
    • 2/3
    • cKIT
    • Spindle cell features
    • Most are non-Aggressive and low malignant potential
    • Gleevec
  12. Image Upload 12see this tumor arising from Muscilaris Propria of the gastric wall, what is it?
    GIST tumor
  13. Image Upload 14This is a slide of a c KIT positive tumor. What is it?
  14. What cells do you see in:
    • - Broners glands (make Bicarb)
    • - Heneth cells
    • - Peyers patches
  15. Image Upload 16What are we looking at?
    Thiss is a pic of the Small intestine

    Note: Pilli and Goblet cells
  16. What are the Congenital Abnormalities in the small and large bowel?
    • Atresia and stenosis
    • Meckel Diverticulum
    • Hirschsprung Disease (Congenital Aganglionic Megacolon)
  17. What is Meckel Diverticulum?
    Where is it found?
    is it a true Diverticulum? What does this mean?
    are they Symptomatic?
    • •Failure of involution of the vitelline duct
    • Antimesenteric, found in distal ileum, within 1 m. of ileocecal valve
    • •True diverticulum, it contains all three layers of the bowel wall (mucosa, submucosa and muscularis propria)
    • - Most are asymptomatic
  18. Image Upload 18Image Upload 20
    Meckels Diverticulum
  19. What is Hirshsprung Disease (MEGA COLON)?
    What is always affected? What areas are usually affected?
    If the Mega colon perforates, it does this in the ______.
  20. •Portion of colon that lacks both Meissner submucosal and Auerbach myenteric plexuses (failed to migrate during divelopement)
    • •Rectum is always affected. The Rectum and the sigmoid are usually affected.
    • - Males are affected more
    • - can be genetic
    • -Cecum
Card Set
Path Block 3 (GIb)
Path Block 3 (GIb)