liver biochem.txt

What are two main plasma proteins created by the liver?
- 1) albumin
- 2) clotting proteins
What is the classic lobule based upon?

Blood flow to center CV
What is the portal lobule based upon?

bile flow to the central Bile Duct
What is the hepatic acinus based upon?

arterial blood flow through 3 regions
What area of the hepatic acinus has the highest O₂ level?

region 1
What area of the hepatic acinus has the highest insulin level?

Region 3
What hepatocytes of the hepatic acinus perform ATP-required functions?

Periportal hepatocytes (b-oxidation, urea cycle, protein synthesis, gluconeo.)
What hepatocytes perform drug metabolism?

Perivenous (Cytochrome P450 system)
What hepa. perform glutamine synthesis?

Perivenous
What occurs in the two metabolic phases of xenobiotics?
- Phase I: hydroxylation
- Phase II: subgroup addition
What two molecules are either created or inhibited because of drug use?
- Superoxide radicals are created
- GSH is inhibited = H₂O₂ increases
Are drugs activated or inactivated through CP450 metabolism? What is the exception?
- Generally inactivated
- Exception: Activation of amines from grilled food. Converts them into carcinogens.
Why are drugs dangerous for habitual drinkers?

The CYP2E1 is really active which causes quick breakdown of drugs. This releases superoxide radicals and decreases GSH (increasing Hydrogen Peroxide) which are both dangerous to the body.

Author

kepling

47050

Card Set

liver biochem.txt

Description

liver biochem

Updated

2010-11-03T16:48:50Z

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