What is the dangerous UCB threshhold?
What are the two causes of Neonatal jaundice?
1) insufficient protein synthesis so lack of Albumin
2) huge RBC turnover from maternal RBC's in baby
What is kernicterus?
When UCB enters the brain and causes encephalopathy.
UCB levels rise above 20
How does blue light therapy help with jaundice?
UCB has hydrogen bonding going on in various places
Blue light breaks these bonds and makes UCB slightly amphipathic
UCB is then excreted in the urine
Why does a person turn yellow when they have jaundice?
UCB is hydrophobic
Elastin is hydrophobic
There is a hydrophobic/hydrophobic interaction
What is Type I C-Najjar Syndrome and what is the UCB level?
no GT = UCB >20
**use light daily but generally does not work for long because of thickening skin with age and lack of penetrance
What is Type II C-Najjar Syndrome and what is the UCB level?
Dysfunctional GT = UCB < 20 = less dangerous and less fatal than Type I
What is Gilbert Syndrome?
Defective promoter region for GT = less GT produced