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FIVE FUNCTIONS OF HORMONE SYSTEM
- 1. DIFFERENTIATION OF REPRODUCTIVE AND CNS OF FETUS
- 2. GROWTH OF KIDS AND TEENS
- 3. MAKE AND FEMALE ORGANS
- 4. MAINTAIN INTERNAL ENVIRONMENT
- 5. EMERGENCY DEMANDS
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LIPID SOLUBLE HORMONES
- ANDROGENS
- ESTROGENS
- PROGESTINS
- GLUCOCORTICOIDS
- MINERALOCARTICOIDS
- THYROID
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POSTERIOR PIT
- GET INFO (VIA NERVES) AND HOMORONES FROM HYPOTHALAMUS
- STORES ADH AND OXYTOCIN
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ANTEROIR PIT
- SLOWER RELEASE OF HORMONES CAUSE MUST RECIEVE RELEASING HORMONE FROM HYPOTHALMUS
- LIKE CORTICOTROPIN RELEASING HORMONE
- THYROTPOIN RELEASING
- GROWTH HORMONE RELEASING
- GONADOTROPIN RELEASE
- THEN IT CAN RELEASE THE HORMONE
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ANTERIOR PIT HORMONES TO KNOW
- CORTOCOTROPIN - ACTH
- SOMATOMAMMOTROPINS- GROWTH HORMONE(BODY) AND PROLACTIN(BREAST)
- GLYCOPROTIENS-TSH
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THYROID GLAND
- CELL TYPES
- FOLLICULAR CELL-MAKE THYROID HORMONE T3 +T4 (STORED IN COLLOID CELL)
- PARAFOLLICULAR- MAKE CALCITONIN (FOR CA++)
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PARATHYROID GLANDS
- IN THYROID GLAND (4 OF THEM)
- MAKE PTH (TO INCREASE BLOOD CA) ANTAGONIT OF CALCITONIN
- EFFECTS BONE, GI, KIDNEY
- LOW MG AND NORM CA INCREASE PTH
- LOW MAG AND LOW CA LOWER PTH ON TEST
- LOW CA INCREASE PTH
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PANCREAS
- ISLET OF LANGERHANS
- ALPHA CELL-MAKE GLUCAGON (INCREASE BS)
- BETA CELL- MAKE INSULIN (LOWER BS)
- DELTA CELL- SOMATOSTATIN (REGULATE A+B CELL OF PAN), GASTRIN (STOMACH ACID)
- F CELLS- PANCREATIC POLYPEPTIDE
IS MOSTLY PNS ORGAN
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ADRENAL CORTEX
- OUTTER LAYER OF ADRENALS
- NO INNERVATION ALL HORMONES (ACTH)
- MAKES
- GLUCOCORTICOID (CORTISOL)
- MINERALOCORTICOID (ALDOSTERONE)
- ADRENAL ESTROGENS AND ANDROGEN
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GLUCOCORTICOIDS
- EFFECT CARB META
- GLUCOSE BLOOD LEVELS
- ANTIINFLAMM
- SUPRESS ANTIINFLAM RESPONSE
- SLOWS GROWTH
- INFLUNCE AWARENESS AND SLEEP HABIT
- UP EATING
- UP ERTHROCYTE FORMATION
- CORTISOL
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MINERALCORTICOODS
- AFFECT ION TRANSPORT
- UP NA PUMP OF EPITHELIAL CELL
- NA K AND WATER RETENTION
- REGULATED BY REINE- ANGIOTENSIN
- ALDOSTERONE
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ESTROGEN AND ANDROGENS
- ESTORGEN SECRETION IS MINIMAL
- ANDROGEN IS WEAK BUT IS CONVERT TO TESTOSTERONE IN TISSUE
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MECH OF COMMUNICATION
- AUTOCRINE- IN CELL
- PARACRINE- LOCAL CELLS
- ENDOCRINE- REMOTE CELLS
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CLASSIFICATIONS OF HORMONES
- STRUCTURE
- ORIGIN
- EFFECTS
- CHEM COMPOSITION
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HOROMONE TRANSPROT
- WATER SOL ARE FREE AND UNBOUND
- LIPID SOL ARE BOUND AND NEED CARRIER (PROTEIN LIKE
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HOW WATER HORMONES WORK
- BIND TO CELL SURFACE RECEPTOR
- G PROTIENS ARE LINKED THEN TO
- SIGNAL GENERATOR THEN
- SECOND MESSENGER THEN
- ACTIVATION OF INTRACELLUAR ENZYME (PROTIEN KINASE A OR C)
- LEADS TO GENE TRANSCRIPTIONS
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SECOND MESSAGERS
- G PROTEINS
- cAMP
- cGMP
- PHOSHOLIPASE
- CALCIUM
IT IS WHAT DOES THE WORK
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PHOSPHOLIPASE C ACTIVATION
- PIP2+ GTP= IP3
- IR3 RELEASE CA FORM ER
- CA THEN ACTIVATES IT
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cAMP ACTIVATION
- ATP WITH ADENYL CYCLASE MAKE cAMP
- THEN cAMP ACTIVATES PKA THAT ACTIVATING OR INHIBITING
- CARDIAC CELL THEN HOLD CA++ FOR STRONG CONTRACTION OF HEART
- IF GOES ON TOO LONG LEADS TO AUTODESTRUCTION OF CELL
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cGMP ACTIVATION
- GTP TO cGMP
- ACTIVATE KINASE
- LEADS TO ACTIVE OR INHIBITS PROTIENS
- MOSTLY ACTH = PNS
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