MS1, Block 2 Cancer Ihnatt

Most common types of myelosuppression

BRMS are usually human proteins

–FDA APPROVED USE:
•Metastatic renal cell carcinoma (in adults)
–MOA:
•IL-2 is a T cell growth factor
•IL-2 stimulates: helper T cells, cytotoxic T cells, suppressor T cells, and memory T cells
–PKIN:
•IV, half-life of 30-90 minutes
Not orally active

–a very severe, common side-effect of high dose IL-2 treatment
•Usually in the lung
•Due to activated T cells that damage the endothelium (especially in the lung)
–HEME: myelosuppression