HE 31,32,33 Immune Sytems

  1. Define immunity
    reaction of cells and tissues to "non-self or foreign" substances
  2. Define antigen
    what are the four examples of antigens
    Foreign agents

    • Foreign soluble substances
    • Infectious organisms
    • Foreign tissue
    • Transformed cells/tissue
  3. What are the two lines of immune Defenses?
    • Innate System
    • Adaptive System
  4. Innate (natural) immune system is also called what?
    "1st response system"
  5. what are the characteristics of the innate immune system?
    • No previous exposure required (no memory)
    • Immediate and rapid response (seconds to minutes)
    • Non-specific response (stereotypic patterns to antigen)
  6. What are the primary constituents for Innate Immunity?
    • Chemical defense: low pH
    • Physical Barrier: Epithelium (skin mucosa)
    • Secretions: defensins, lysozyme, complement, etc.
    • Cells
  7. What are the cells involved in innate immunity?
    • Mast cells
    • Neutrophils (all granulocytes involved)
    • Macrophages
    • +NK cells (Natual Killer cells)
  8. What are APC's used for?
    • 1. To link the innate and adaptive immune systems
    • 2. They are part of the adaptive immune system
  9. What are the general characteristics of the adaptive immune system
    • Delayed response (days, weeks, years)
    • Diverse in recognition of antigens
    • Diverse and specific response to antigens
  10. Adaptive immune system depends on self "__________"
  11. Define autoimmune disease
    loss of ability of cells to discriminate between self and antigen
  12. Primary cells involved in adaptive immunity
    • Antigen presenting cells
    • lymphocytes (B and T cells) work cooperatively, signal each other via cytokines
  13. what are the two primary results of lymphocyte activation?
    Production of effector cells- fight antigen NOW, specific expansion of lymphocytes via mitosis, these are the warrior cells

    Generation of memory cells- specific for that antigen in the FUTURE
  14. B Cells
    what type of immune response?
    Humoral (antibody) immune responses
  15. B Cells
    attack antigen by?
    direct chemical bombardment
  16. activation of a B-cell specific for an antigen results in:
    • effector cells- Fight now
    • plasma cells- persistent antibodies made, then dumped into interstitial fluid, lymph or blood
    • B-memory cells- fight in the future
  17. T-cells
    what type of immune response?
    Cell mediated
  18. T-cells
    attack antigen by?
    attack antigens cell-to-cell (directly or indirectly)
  19. T-cells
    activation requires?
    APC's. AnP-MHC binds to T-cell receptors
  20. activation of a T-cell specific for an antigen results in:
    • effector cells-fight now, cytotoxic T-cells, T-Helper cells, T-suppressor cells, (others)
    • T-memory cells- antigen specific, fight in the future
Card Set
HE 31,32,33 Immune Sytems
Histology of the lymphoid organs