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MS1, Block 2 Cholinergic Drugs
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Choline esters
Acetylcholine
Bethanechol
Carbachol
Methacholine
(ABCM)
Anticholinesterase agents (agents that indirectly increase cholinergic function)
Reversible agents
Physostigmine
Neostigmine
Edrophonium
Ambenonium
Pyridostigmine
Donepezil
Tacrine
Naturally occurring cholinergic stimulants
Muscarine
Nicotine
Pilocarpine
Choline ester that is partially refractory to AChase breakdown and is valuable as an experimental tool.
Methacholine
Choline ester that is very refractory AChase breakdown and has mostly nicotinic stimulating effects.
Carbachol
Choline ester with well established clinical utility. Refractory to AChase inactivation and has mostly muscarinic stimulating effects.
Bethanechol
Useful in treating post-operative urinary retention and atony of the GI tract.
Bethanechol
Naturally occurring cholinergic stimulant that activates all autonomic ganglia and stimulation of skeletal muscle.
Nicotine
Naturally occurring cholinergic stimulant that will stimulate all innervated and non-innervated muscarinic receptors.
Muscarine
Good antidote for rapid onset type (muscarine) poisoning.
Atropine
Naturally occurring cholinergic stimulant that selectively activates muscarinic receptors. Highly charged and readily crosses membrane barriers.
Pilocarpine
Cholinergic stimulant used to treat glaucoma.
Pilocarpine
Reversible AChase inhibitors
Physostigmine
Neostigmine
Edrophonium
Pyriostigmine
Donepezil
Tacrine
(DENT are PPs)
AChase inhibitor that is not highly charged (teritary amine) and can readily enter the CNS.
Physostigmine
AChase inhibitor used for treatment of atropine poisoning.
Physostigmine
AChase inhibitor that is charged (quaternary amine) and does not readily enter the CNS.
Neostigmine
AChase inhibitor used to reverse actions of competitive neuromuscular blocking (curare-like) drugs.
Neostigmine
Long-acting AChase inhibitor used to treat myasthenia gravis.
Pyridostigmine
AChase inhibitor with a short duration of action that is valuable for the diagnosis of myasthenia gravis.
Edrophonium
CNS acting AChase inhibitors that are used to treat cognitive dysfunction in Alzheimer's patients.
Donepezil and Tacrine
Irreversible AChase inhibitor used to treat glaucoma, but restricted to aphakic eyes due to high incidence of cataract formation.
Echothiophate
Irreversible AChase inhibitors that are commonly used as insecticides
Parathion and Malathion
Potent anti-cholinesterase war gases.
Sarin and Soman
AChase reactivator that is used to treat intoxication by organophosphates.
Pralidoxime (2-PAM)
Prototypical muscarinic blocking drug that produces CNS excitation resulting in slight paradoxical bradycardia.
Atropine
Characteristics of atropine poisoning.
Hot, dry skin. Dilated pupils.Maniacal behavior. (Red as a beet, hot as a pistol, dry as a bone, and mad as a hatter)
Muscarinic blocker that causes CNS depressant effects.
Scopolamine
Muscarinic blocker used to treat motion sickness.
Scopolamine
Less potent and short-acting muscarinic blocker used to cause mydriasis and cycloplegia for ophthalmological exams.
Tropicamide
Synthetic muscarinic antagonists that do not enter the CNS and are used primarily in patients with COPD.
Ipratropium and Tiotropium
Second line drug for treatment of bronchial asthma. Appears to be beneficial when combined with other bronchodilators.
Ipratropium
Longer duration of action than Ipratropium and can be used as a once/day drug.
Tiotropium
CNS acting muscarinic blocker that is used to relieve symptoms of Parkinson's disease.
Benztropine
Muscarinic blocker used to treat spasms of the bladder after urologic surgery and in some neurological disorders producing bladder hyperactivity.
Oxybutynin
Prototypic ganglionic blocking drug. Does not compete with ACh at nicotinic receptors at the endplate region of skeletal muscle.
Hexamethonium (H6)
Predominant tone and effect of ganglionic blockade on arterioles
Sympathetic
Vasodilation
Predominant tone and effect of ganglionic blockade on veins
Sympathetic
Dilation
Predominant tone and effect of ganglionic blockade on the heart
Parasympathetic
Tachycardia
Predominant tone and effect of ganglionic blockade on the iris
Parasympathetic
Mydriasis
Predominant tone and effect of ganglionic blockade on ciliary muscle of the eye
ParasympatheticCycloplegia
Predominant tone and effect of ganglionic blockade on the GI tract
Parasympathetic
Reduced tone and motility
Predominant tone and effect of ganglionic blockade on the urinary bladder
Parasympathetic
Urinary retention
Predominant tone and effect of ganglionic blockade on salivary glands
Parasympathetic
Xerostomia
Predominant tone and effect of ganglionic blockade on the sweat glands
Parasympathetic
Anhidrosis
Author
BigDee
ID
46462
Card Set
MS1, Block 2 Cholinergic Drugs
Description
Koss's material Adam G made these
Updated
2010-11-02T15:04:35Z
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