TB Rx

  1. INH
    Name, MoA, MoR, Adverse side effects
    • Isoniazid: .
    • Mechanism of Action: Inhibition of mycolic acid synthesis
    • Resistance: Lose catalase & peroxidase needed to activate prodrug
    • Adverse side effects: hepatotoxicity, neurotoxicity
  2. RIF
    Name, MoA, MoR, Adverse side effects
    • Rifampin: .
    • Mechanism of Action: Inhibition of RNA synthesis
    • Resistance: Albeted beta subunit or RNA polymerase
    • Adverse effects: .
    • HEPATOXICITY
    • HYPERSENSITIVITY
    • RED STAINING (CONTACTS TOO)
    • POTENT CYP 450 INDUCTION
  3. PZA
    Name, MoA, MoR, Adverse side effects
    • Pyrazinamide: .
    • Mechanism of action: Depletion of membrane energy
    • Resistance: Lose pyrazinaminidase - nicotinamidase activity (no prodrug activation)
    • Adverse effects: .
    • HEPATOTOXICITY
    • GOUT
    • PHOTOSENSITIVITY
    • not indicated in pregnancy
  4. EMB
    Name, MoA, MoR, Adverse side effects
    • Ethambutol: .
    • Mechanism of Action: Inhibition of arabinogalactan synthesis
    • Resistance: Mutation in gene controlling inhibitor(s)
    • Adverse effects: .
    • RETROBULBAR NEURITIS
    • PERIPHERAL NEUROPATHY
    • HYPERURICEMIA
Author
Anonymous
ID
46298
Card Set
TB Rx
Description
TB Rx svetol
Updated