-
INH
Name, MoA, MoR, Adverse side effects
- Isoniazid: .
- Mechanism of Action: Inhibition of mycolic acid synthesis
- Resistance: Lose catalase & peroxidase needed to activate prodrug
- Adverse side effects: hepatotoxicity, neurotoxicity
-
RIF
Name, MoA, MoR, Adverse side effects
- Rifampin: .
- Mechanism of Action: Inhibition of RNA synthesis
- Resistance: Albeted beta subunit or RNA polymerase
- Adverse effects: .
- HEPATOXICITY
- HYPERSENSITIVITY
- RED STAINING (CONTACTS TOO)
- POTENT CYP 450 INDUCTION
-
PZA
Name, MoA, MoR, Adverse side effects
- Pyrazinamide: .
- Mechanism of action: Depletion of membrane energy
- Resistance: Lose pyrazinaminidase - nicotinamidase activity (no prodrug activation)
- Adverse effects: .
- HEPATOTOXICITY
- GOUT
- PHOTOSENSITIVITY
- not indicated in pregnancy
-
EMB
Name, MoA, MoR, Adverse side effects
- Ethambutol: .
- Mechanism of Action: Inhibition of arabinogalactan synthesis
- Resistance: Mutation in gene controlling inhibitor(s)
- Adverse effects: .
- RETROBULBAR NEURITIS
- PERIPHERAL NEUROPATHY
- HYPERURICEMIA
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