CP 26

  1. How does HIV cause reduced CD4+ T cells?
    • Direct HIV-mediated destruction of CD4 T lymphocytes (explained beneath)
    • Autoimmune destruction of CD4 T lymphocytes
    • Toxicity of viral proteins to CD4 T lymphocytes + marrow suppresstion
    • Induction of apoptosis
  2. How is HIV diagnosed?
    • ELISA + Western blot: presence of anti-p24 and anti-gp120
    • Other tests: CD4:CD8 ratio, viral load, B2 microglobulin
  3. Name 6 classes of drugs for HIV.
    • Nucleoside reverse transcriptase inhibitors (NRTI)
    • Non-nucleoside reverse transcriptase inhibitors (NNRTI)
    • Protease inhibitors
    • Fusion inhibitors
    • Integrase inhibitors
    • Cellular chemokine receptor antagonists

    • Therapy should involve combination of drugs
    • Note: all NNRTI's interacts with other drugs
  4. What are some infections commonly occuring in HIV patients?
    • Lung: CMV, HSC, TB, strep pneumo, H.I, mycobacterium avium, cryptococcus
    • CNS: NM, HSC, cryptococcus
    • GIT: cryptosporidium, m.avium, candida
    • Bones: pneumocystis carinii, m.avium
  5. Name 5 non-infection caused illnesses in HIV patients.
    • Depression
    • Drug-induced myocarditis
    • Thrombocytopenia & bruising
    • Neuropathy/myopathy
    • HIV-associated dementia
Card Set
CP 26