how is unconjugated bilirubin transported even though it is very hydrophobic?
serum albumin (has a variety of binding domains for both hydrophilic and hydrophobic ligands)
how is conjugated bilirubin excreted into the bile?
via ATP-dependent carrier, multidrug resistantce-associated protein 2 (MRP2)
how is urobilinogen formed from conjugated bilirubin?
conjugated bilirubin is metabolized by colonic bacteria yeilding urobilinogen
how is urobilinogen converted to stercobilin?
how much urobilinogen is excreted in the feces as stercobilin?
90%, normal fecal stercobilin test is positive
what is the path of enteropathic recirculation for urobilinogen?
is uncojugated bilirubin filtered by the kidney?
is conjugated bilirubin filtered by the kidney?
unconjugated=not filtered, it is hydrophobic
conjugated=filtered (if present), it is amphipathic
Heme Catabolism and Jaundice