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Lecture 54.txt
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how is unconjugated bilirubin transported even though it is very hydrophobic?
serum albumin (has a variety of binding domains for both hydrophilic and hydrophobic ligands)
how is conjugated bilirubin excreted into the bile?
via ATP-dependent carrier, multidrug resistantce-associated protein 2 (MRP2)
how is urobilinogen formed from conjugated bilirubin?
conjugated bilirubin is metabolized by colonic bacteria yeilding urobilinogen
how is urobilinogen converted to stercobilin?
non-enzymatic auto-oxidation
how much urobilinogen is excreted in the feces as stercobilin?
90%, normal fecal stercobilin test is positive
what is the path of enteropathic recirculation for urobilinogen?
colon-portal blood-liver-bile-intestine
is uncojugated bilirubin filtered by the kidney?
is conjugated bilirubin filtered by the kidney?
unconjugated=not filtered, it is hydrophobic
conjugated=filtered (if present), it is amphipathic
Author
cjharmon311
ID
45785
Card Set
Lecture 54.txt
Description
Heme Catabolism and Jaundice
Updated
2010-10-29T00:53:39Z
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