Lecture 54.txt

how is unconjugated bilirubin transported even though it is very hydrophobic?

serum albumin (has a variety of binding domains for both hydrophilic and hydrophobic ligands)
how is conjugated bilirubin excreted into the bile?

via ATP-dependent carrier, multidrug resistantce-associated protein 2 (MRP2)
how is urobilinogen formed from conjugated bilirubin?

conjugated bilirubin is metabolized by colonic bacteria yeilding urobilinogen
how is urobilinogen converted to stercobilin?

non-enzymatic auto-oxidation
how much urobilinogen is excreted in the feces as stercobilin?

90%, normal fecal stercobilin test is positive
what is the path of enteropathic recirculation for urobilinogen?

colon-portal blood-liver-bile-intestine
is uncojugated bilirubin filtered by the kidney?
is conjugated bilirubin filtered by the kidney?
- unconjugated=not filtered, it is hydrophobic
- conjugated=filtered (if present), it is amphipathic

Author

cjharmon311

45785

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Lecture 54.txt

Description

Heme Catabolism and Jaundice

Updated

2010-10-29T00:53:39Z