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3 pieces of interphase and describe
- g1-growth of cell
- S-synthesis of DNA (2 sister chromosomes produce)
- g2-chromosomes condense
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3 checkpoints in cell
- G1S-cell splits
- G2M-Commitment to mitosis
- Spindle-all chromosomes attach (late metaphase)
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How does Eukrayotic divison differ from pro?
- Pro- much simplier, binary fussion
- single dna molecule attaches to copy
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whats being seperated in meiosis 1 in anaphase
homologous chromosomes
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being seperated during anaphase in meio 2
sister chromotids
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discribe difference btwn haploid and diploid
- hap- end of meio 1
- dip-end of meio 2
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binary fussion
division of bateria. the single circular bacterial chromo is replicated.
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septum
forms to divide the ccell into 2 cells
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chromatin
a complex of DNA and protiens that eukaryotic chromosoms are made out of
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heterchromatin
not expressed in Eukary. chromosomes
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euchromatin
expressed in regions in eukary chromosomes
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karyotype
particular array of chromosomes of an organism
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kinetochores
center where replicated chromosomes are connected to each other
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cohesion
complex of protiens holding replicated chromosomes together
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sister chromatids
2 copies of the chromosome within the replicated chromosome
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eukaryotic cell cycle
interphase (g1,s,g2), mitosis, cytokenisis,
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condensation
during G2 when chromosome become tightly coiled
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centrioles
(microtubule-organizing centers) replicate and one cetriole moves to each pole
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prophase
chromosomes condense, centrioles move to each side of cell, spindles are assembled, nuclear envelope dissolves.
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prometaphase
- (Attachment phase)
- chromosomes become attached to spindle by kinetochores, second set of microtubules is formed and begin to pull each chromosome toward center of cell
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metaphase
chromosomes align at center of cell on the metaphase plate
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anaphase
- removal of cohesion protiens causes centromes to seperate, microtubules pull sister chromatids toward the poles,
- (in anaA the kineetochores pull apart but in anaB the poles move apart)
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telephase
- spindles disappear, nucleaur envelople formed around each set of sister chromatids, chromosomes uncoil, nucleaus appears
- redoes prophase
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cytokinesis
when cell splits.
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cleavage furrow
(cytokenisis in animal cell) constriction of actin filaments produces
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checkpoints
- g1/S-cell decides to divide
- g2/M-cell makes commiitment to mitosis
- splindle-late metaphase--ensures all chromosomes are attached to splindle.
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tumor-suppresor genes and proto-oncogenes
- 1.genes that say no, prevent development of many cells containing mutations (ex. p53 halts cell division if damaged DNA is detected)
- genes that say yes
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meiosis
form of cell division that leads to production of gamets
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gamets
- egg and sperm. each contain half number of chromosomes
- haploid (contain 1 set of chromosomes)
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somatic cells
- adult body cells and are diploid meaning they contain set of 2 chromosomes
- our every day cells
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sexual reproduction
- fusion of gamets (fertilization) to produce a diploid zygote
- gamets are sex cells
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synapsis
during meiosis 1 when homologous chromosomes become closely associated with each other
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synaptonemal complex
protiens btwn the hologues hodl them
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crossing over
- copy and paste of DNA
- genetic recomb. btwn non sister chromatids
- physical exchange of regions btwn chromatids
- it occurs in the chiasmata
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Meiosis 1
- p-chromosomes coil 2gther, nuclueas dissolves, homolgues associates closey with snapsis, crossing over occurs
- M- terminal chaismate hld homolo 2gther after crossing over, microtubules attach to each homo...NOT SISTER CHORTIDS, align randomly
- A- splindle shorten, homolo are separated, sister chromatids are attahced to other at cetromeres
- T- nucleur envelope form around each chromosome, new nuclues is now hap, sister chroma no longer identical bcus of C.Over
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Meiosis II
resembles mitotic divison
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Meiosis VS. Mitosis
- Meiosis-synapsis & c.over, sister chrom remain joined at cetromeres throughtout meio1, knetochores of sister attach to same pole in meio1, dna rep is supressed btwn 1 nd 2, produce haploid and arent ident. random alignment
- mitosis-produce 2 cells identical to each otehr
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f1 generation
offspring of 2 truebreeding strains, resemble only 1 parent
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f2 generation
offspring resul from self-fert. of f1 plants.
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gene & allele
information for a trait passed from parent to offspring
allele-alternate form of gene
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geno and pheno
- geno-total set of allels of an indvidual
- PP=homo dom, pp=homo rec. Pp=hete
- pheno-physical
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Principle of segregation
two alleles for a gene segrgate during gamet formation and re rejoined at random, one from each parent during fert.
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pedigree analysis
track inheritance patterns in families
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pleiotropy
refers to an allele which has more than one effect on the phenotype
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extensions to mendel
- each trait controled by single gene
- each gene has only 2 alleles
- clear dom-rec relationship between alleles
- polygenic inheritance
- incomplete domin
- codominance
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epistasis
one gen can interfere with the expression of another gene (kitty)
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chromosome theory
- Walter Sutton (1902)
- genes present on chromosomes
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