-
NRTI Class AE, SC
- Lactic Acidosis w/Hepatic Stenosis
- Renal Adj (ex ABC) when GFR <60ml/min
- Don't act through CYP
-
zidovudine
- NRTI
- Retrovir (AZT)
- 1) BMSup
- 2) Anemia
- 3) Fatigue, myalsia
- DI: antag w/d4t
-
didanosine
- Videx (ddi)
- 1) pancreatitis
- 2) peripheral neuropathy
- DI: TDF increases Conc
- SC: WBD - usually empty stomach (w/TDF w/food)
-
Stavudine
- (Zerit) (D4t)
- 1) Lipoatrophy
- 2) Hyperlipidemia
- DI: AZT
- SC: Fallen out of favor - weight based dosing
-
Lamivudine
- (Epivir) (FTC)
- hyperpig of palms & soles
- don't combine
- similar
- HEPB activity
-
Abacavir (Ziagen, ABC)
- 1) risk of MI
- 2) hypersensativity
- SC: no renal adj
-
Tenofavir
- Viread (TDF)
- preferred
- 1) nephrotox
- 2) GI, flatulence
- DI: ddI & ATV
- SC: Activity vs. HBV
-
NNRTI Class effects
- AE: Rash & Hepatotox
- DI: Impact CYPsystem
- SC: lower genetic barrier to resistance
-
Nevirapine
- (Viramune, NVP)
- not for: men CD4>400
- women CDR>250
- DI: metal by 3A4, cyp inducer
- SC: dose titrate to start
-
Efavirenz
- (Sustiva) (EFV)
- 1) CNS - dreams
- DI: mixed CYP inh/ind
- Food inc conc - Empty Stomach
- SC: teratogenicity, false positive cannaboid test
-
Delaviridine
- (Rescriptor, DLV)
- Fallen out of face - less potent, more frequent dosing
-
Ertavirine
- (Intelence, ETR)
- AEL GI
- mostly for resistance
- with food, BID dosing
- induces 3a4, inhibit 2c9
-
Raltegravir
- (Isentresss, RAL)
- AE: GI, HA, ELevations in CPK
- DI: dec by rif
- SC: BID dosing, hep metal, gen well tolerated
-
PI CLass
- Higher barrier to resistance
- hep metab - no renal adj
- Lipid changes, Insulin resistance, elevated transminases, GI upset, bleeding in hemos
- DI: all metal by 3a4, all induce 3a4
- most with food
-
Ritonavir
- (Norvir, RTV)
- taste, paresthesias, hepatits
- **DOSING - tabs - NO REFRID)
-
Indinavir
- (Crixivan, IDV)
- Nepprholithiasis, hyperbilli
- ES (unboosted)
-
-
Kaletra
- Lopinavir/Ritonavir - KTA
- N/D, panc - tab - no food & fridge
-
Atazanavir
- (Reyataz, ATV)
- Hyperbilli, ATC, nephrolithiasis
- DDIs: acid sup, TDF
-
Fosamprenavir
- Rash, paresthesias
- Sulfa caution
- w/ or w/o food
-
Tipranavir
- (Aptivus, TPV)
- Hepatitis, rash, ICH
- Sulf caution
-
Darunavir
- (Prezista, DRV)
- Rash - Sulfa - Caution
- preferred
-
Combivir
Lamivudine & Zidovudine
-
Trizivir
Lamivudine, Zidovudine, Abacavir
-
Epzicom
Lamivudine & Abacavir
-
Truvada
Emtricitabine & Tenofovir
-
Atripla
Emtricitabine & Tenofavir & EFA
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