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Dosage forms exam 1 Stabilizatioon

  1. T/F Increased temperature decreases degradation rate
    False! Decreased temp Decreases degradation rartes
  2. Buffers to formulate pH
    Phosphate and Citrate
  3. Lypophilization
    Solvent loving, freeze drying
  4. Process of lypophilization
    Frozen product-sublime-dry product

    Removes frozen water and pores remain where crystals were.
  5. Oil soluble antioxidants used for stability
    Vitamin E (Alpha-tocopherol)
  6. Water soluble antioxidants used for stability
    Vitamin C and sodium sulfite
  7. Two principal mechanisms of antioxidant action
    • Stop propagation
    • Preferentially oxidized
  8. Minimize metal content by using
    chelators
  9. Examples of chelators
    Citric Acid, EDTA
  10. Ultraviolet light wave length
    185-380 High energy and absorbed by most drugs
  11. Responsibilites of pharmacist
    • Rotation- stock and observe exp dates
    • Storage- under recommended conditions
    • Observing- color or smell
    • Proper treatment- treat right
    • Informing- and educating patient
Author
swynocker
ID
45370
Card Set
Dosage forms exam 1 Stabilizatioon
Description
Stabilzation
Updated

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