Opioids

Home

Get App

Create

Mu 1
- supraspinal analgesia
- miosis
- euphoria
- alters perception to pain
- N/V
Mu 2
- respiratory depression
- sedation
- spinal analgesia
- CV effects-bradycardia
- slowed gastric emptying
- physical dependence
Kappa
- sedation
- spinal analgesia
- miosis
- respiratory depression (?)
Sigma
- sydphoria
- hallucinations
- respiratory stimulation
- muscle rigidity
- tachycardia
- mydriasis
delta
- supraspinal analgesia
- spinal analgesia
- behavioral
- physical dependence
- epileptogenic
What distributive property accounts for the speed of onset of Fentanyl?

Lipid Solubility
What distributive property accounts for the speed of onset of Sufentanil?

Lipid solubility
What distributive property accounts for the speed of onset of Alfentanil?

highly nonionized
What do we know about morphine from it's distributive properties?
- slow passage across BBB
- slow onset and long duration of action
What do Fentanyl and Sufentanil's distributive properties tell us about how they work?
- Very high lipid solubility means a rapid onset and short duration of action.
- High lipid solubility also increases first pass effect in lungs
What do alfentanil's distributive properties tell us about how it works?
- highly nonionized allows it to cross the BBB so rapid acting.
- small Vd due to PRO binding allows for quick redistribution of alfentanil
Which opioids metabolize to active metabolites?
- Meperidine=Normeperidine which is CNS excitatory
- Morphine=Morphine 6 glucuronide which is more potent and longer lasting than morphine
Which opioid is metabolised through ester hydrolysis?

Remifentanil
Which opioids should be avoided in renal patients?

Morphine and Meperedine due to their active metabolites.
What causes muscle rigidity?

High does, especially fentanyl and it's derivatives.
What is the area stimulated to cause miosis?

Edinger-Westphal

Author

Anonymous

45332

Card Set

Opioids

Description

Opioid flash cards

Updated

2010-10-27T03:12:48Z

Show Answers