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DISTRIBUTION OF BODY FLUIDS INCLUDES:
- ICF
- ECF
- INTERSTITIAL
- INTRAVASCULAR
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ICF
- Fluid inside cells
- about 40% of total body weight
- 2/3 of total body fluid
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ECF
- about 20% of total body weight
- 1/3 of total body fluid
- fluid outside cell
- composed of : Intravascular and Interstitial
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Intravascular
Blood plasma
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Interstitial
called 3rd space
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Solute
Substance dissolved in a solution
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Solvent
Liquid with a substance in solution
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Non diffusable substance
ie - plasma protein
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Movement of Body Fluids includes:
- Osmosis
- Difusion
- Osmotic Pressure
- Colloid Osmotic Pressure
- Filtration
- Active Transport
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Osmosis
Movement of a SOLVENT through a membrane from higher to lower conc. through a semipermeable membrane
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Diffusion
Movement of a SOLUTE from an area of higher concentration to lower conc. thru semipermeable membrane
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Concentration of Fluids include:
- Isotonic
- Hypotonic
- Hypertonic
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Isotonic
Same solute concentration
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Hypertonic
Higher solute conc.
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Hypertonic
Lower solute conc.
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Osmotic Pressure
- Drawing power for water (solvent).
- Depends on number of molecules in solution (concentration)
- depends mostly on sodium
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Colloid Osmotic Pressure
- Osmotic pressure created by plasma proteins which are too big to normally pass through capillary membrane
- most important protein responsible: ALBUMIN
- This pressure keeps fluid in the Intravascular Compartment
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Filtration
- Movement of water and diffusible substances in response to fluid pressure (hydrostatic pressure)
- Normally venous pressure is lower than interstitial pressure which allows movement into venous system
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Active Transport
- Requires energy to transport material across cell membrane
- larger molecules than normally admitted such as glucose
- movement of substances from area of lower to higher concentrations, such as sodium potassium pump
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Aldosterone
- Responds to increased K+ levels
- promotes reabsorption of Na+ and excretion of K+ = reabsorption of water
- Angiotensin II stimulates release of Aldosterone
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Renin
- enzyme secreted by kidneys in response to decreased renal perfusion
- Acts to produce angiotensin I and II which causes slective constriction and increased blood flow to kidneys
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Measuring I & O
- after sx
- unstable condition
- Temp increase
- fluid restriction
- on diuretic or IV
- chronic cardiopulomary
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Fluid Output Regulation
- Skin - insensible water loss- continuous not perceived
- sensible water loss - thru excessive sweat
- Kidneys - respond to decreased volume or increased osmolality
- Gi Tract - Normally very little output, unless disease process (diarrhea, vomiting)
- Lungs
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Normal loss thru GI (bowels)
100/200 ml/day (insensible)
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sever diarrhea can increase output to
2000-3000 ml/day (sensible)
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Normal loss through skin is
Insensible
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excessive sweating, fever, burns can significantly increase loss thru skin is
Sensible
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Function of Electrolytes
- Nerve Impulse Transmission
- Skeletal and Cardiac muscle function
- Acid-Base Balance
- Hormone Balance
- Water Balance
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Sodium NA+
- most abundant electrolyte in ECF
- Maintains water balance
- Important for transmitting nerve impulses and muscle contraction
- regulated by salt intake, aldosterone, UO
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Low sodium levels
causes:
- by taking in too much water, overhydration
- decrease in sodium
- symptoms: decreased LOC, sensorium, weakness, fatigue,
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High sodium causes
- caused: Dehydration
- Sx: similar to low level symptoms -- decreases LOC, disorientation, weaknes,, fatigue, THIRST
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Normal Sodium Values
135-145
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Potassium
- most abundant in ICF
- Important in neuromuscular excitability and muscle contraction and electrical conductivity
- Involved in acid-base balance bc it can be exchanged with H+
- Regulated by kidneys : as K+ levels rise, kidneys excrete more K+
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Aldosterone causes
Kidneys to retain NA+ and excrete K+
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Potassium low levels
- causes: Diuretics and vomiting
- S&S: cardiac dysrythmias, muscle cramps
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Potassium High levels (HYPERKALEMIA)
- causes: renal disease, crush injuries
- S&S -cardiac abnormalities
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Calcium
- found in bones and teeth
- only 1% of body's Ca+ is in serum
- imp. for cell membrane integrity
- imp in cardiac impulse
- affects contraction of cardiac, smooth, and skeletal muscle
- involved in blood coagulation
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Magnesium
- second most abundant cation in ICF
- promotes enzyme reactions
- helps body produce ATP
- influences Ca levels
- 30% of circulating Mg is bound to ALBUMIN
- =low albumin = low Mg
- alterations in MG = SERIOUS ILLNESS
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Chloride
- Most abundant anion in ECF
- imp for fluid acid and base balance
- contributes to gastric acid
- regulated by kidneys
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Co2 Value
24-30 an indirect measure of bicarbonate
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Bicarbonate
- major ECF buffer in blood
- Functions with carbonic acid in maintaining acid-base balance
- Measured in venous blood indirectly as carbon dioxide content
- Regulated by kidneys
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Phospate
- Buffer Ion
- Helps maintain healthy teeth and bones
- regulated by kidneys
- calcium adn phosphate are inversley proportional
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Physiological rxn of lungs
- respiration increases or decreases in respoonse to changes in pH
- works by changing blood levels in CO2
- rapid response to changes in pH
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Kidneys Physiological Reaction
- Reabsorb or excrete bicarbonate and hydrogen in response to changes in pH
- takes from several hours to several days to regulate balance
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ECF Volume Deficit: Isotonic
HYPOVOLEMIA
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Hypovolemia
- common with electrolyte loss
- causes: Vomiting/Diarrhea
- GI suctioning
- Hemorrhage
- Burns
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S&S of Hypovolemia
- decreased BP
- Orthostatic BP Changes
- Increased HR
- decreased UO
- dizzy
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Treatment of Hypovolmia
- volume expanders- ALBUMIN
- this pulls fluid that has been sequestered in 3rd space
- O2
- Vasopressors
- Trendelenburg position
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ECF VOLUME DEFICIT-DEHYDRATION
- S&S: increased sweating
- diarrhea
- decreased mental status
- dry mucous membranes
- poor skin turgor
- thirsty
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dehydration-
- sodium increases and volume decreases
- major dif between hypovolmia and dehydration- is the cells are dehydrated
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causes of dehydration
- fever
- excessive sweating
- diabetis insipidus
there is a shift of volume from cells and interstitial
treatment-give pt hypertonic fluid (dont do this in short amount of time)
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ECF Volume Excess - HYPervolemia
- 2 issues: fluid overload & electrolyte overload
- excess isotonic fluid in extracellular compartment
- caused by: excessive isotonic fluid intake--excess Na+
- usually body compensates by excreting h20 and Na+
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If Hypovolemia is sudden or due to weak cardiac muscle (CHF)
- can result in pulmonary edema
- hydrostatic pressure forces fluid out of vascular space into interstitial spaces and eventually alveoli of lung and interferes with oxygen exchange
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S&S of HYPERvolemia:
- increased BP
- Edema
- SOB
- decreased Sats
- early stages- increased UO
- later stages- decreased UO
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Treatment of Hypervolemia
- restrict fluid, NA+ intake
- diuretics
- address cause
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ECF Volume Excess HYPOOSMOLAR
- less common
- water intoxication
- excess hypotonic fluid in extracellular space
- results in fluid moving to intracellular space-cellular edeuma
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Hypoosmolar causes
- SIADH
- rapid infusion of hypotonic fluids
- excess use of tap water enemas
- causes serum osmolality decreases
- fluid shifts into cells
- sodium decreases
- cererbral edema
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treatments of Hypoosmolar
- replace solutes to draw water out of cells
- fluid restriction
- increase hypertonic solution of sodium --dont do fast
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Normal Saline
0.9% sodium chloride
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